Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid
Taiwan Journal of OphthalmologyPURPOSE: The purpose of the study was to study the efficacy of oral cyclophosphamide monotherapy in advanced resistant ocular cicatricial pemphigoid (OCP).
Arash Maleki +9 more
doaj +1 more source
Antibody-Mediated Extreme Insulin Resistance: The Importance of Pre-Treatment Screening
Case Reports in Endocrinology, 2019 We report the case of a 56 year-old Hispanic male with a 10-year history of type 2 diabetes who presented with abrupt onset of hyperglycemia resistant to escalating doses of intravenous insulin infusion (>2500 units daily). He was diagnosed with antibody-
Tina Mosaferi +3 more
doaj +1 more source
Case Report: COVID-19 Vaccination Associated Fulminant Myocarditis
Frontiers in Cardiovascular Medicine, 2022 Herein, we describe a novel finding of fulminant myocarditis (FM) in two subjects the day after administration of the first dose of the currently available inactivated SARS-CoV-2 vaccine (Vero cell).
Guanglin Cui +7 more
doaj +1 more source
Inclusion body myositis: therapeutic approaches. [PDF]
, 2012 The idiopathic inflammatory myopathies are a heterogeneous group of diseases that include dermatomyositis (DM), polymyositis (PM), inclusion body myositis (IBM) and other less common myopathies.
Aggarwal, Rohit, Oddis, Chester V
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
SARS-CoV-2 immune responses in patients with multiple myeloma and lenalidomide maintenance therapy
Frontiers in ImmunologyIntroductionMultiple myeloma (MM) is an uncontrolled plasma cell proliferation in the bone marrow, leading to immune dysregulation with impaired humoral immune responses. Conversely, cellular-based responses play a vital role in MM patients. However, the
Ioana Martac +12 more
doaj +1 more source
Use of monoclonal antibodies in patients with multiple sclerosis in the practice of a neurologist
Медицинский совет, 2020 Multiple sclerosis (MS) ranks first for prevalence among diseases affecting the CNS white matter with 2.5 million cases estimated globally. InRussia, the number of cases is about 200 thousand.
N. Yu. Lashch
doaj +1 more source
Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]
, 2019 Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub +7 more
core +1 more source
Inhibiting tryptophan metabolism enhances interferon therapy in kidney cancer. [PDF]
, 2016 Renal cell carcinoma (RCC) is increasing in incidence, and a complete cure remains elusive. While immune-checkpoint antibodies are promising, interferon-based immunotherapy has been disappointing.
Abu Aboud, Omran +13 more
core +2 more sources