Results 61 to 70 of about 249,886 (308)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Autoinjector preference among patients with multiple sclerosis: results from a national survey

Patient Preference and Adherence, 2017
V Limmroth,1 J Reischl,2 B Mann,3 X Morosov,2 A Kokoschka,2 I Weller,2 T Schreiner2 1Clinic for Neurology and Palliative Medicine, Municipal Hospital Köln-Merheim, Cologne, 2Bayer Vital GmbH, Leverkusen, 3IFAK Institute GmbH & Co.
Limmroth V, Reischl J, Mann B, Morosov X, Kokoschka A, Weller I, Schreiner T   +6 more
doaj  

Immunological Mechanisms and Effects of Bacterial Infections in Acute-on-Chronic Liver Failure

Cells
Acute-on-chronic liver failure (ACLF) is a severe clinical syndrome characterized by high morbidity and mortality rates. Bacterial infection is a frequent precipitating factor and complication in ACLF patients, significantly worsening patient outcomes ...
Sumeng Li, Jing Liu, Jun Wu, Xin Zheng
doaj   +1 more source

Therapeutic effect of mesenchymal stem cell on Hashimoto’s thyroiditis in a rat model by modulating Th17/Treg cell balance

Autoimmunity, 2020
The autoimmune condition Hashimoto’s thyroiditis (HT) is a disease wherein lymphocytes mediate the autoimmune damage and destruction of the thyroid gland.
Yongjun Cao, Xiaowen Jin, Yumeng Sun, Weibo Wen   +3 more
doaj   +1 more source

Optimization of immunoglobulin substitution therapy by a stochastic immune response model [PDF]

, 2009
Background: The immune system is a complex adaptive system of cells and molecules that are interwoven in a highly organized communication network. Primary immune deficiencies are disorders in which essential parts of the immune system are absent or do ...
Marc Thilo Figge, Derya Unutmaz, E Mix, CA Janeway, ICM MacLennan, T Manser, M Meyer-Hermann, MT Figge, L Marodi, OC Bruton, RH Buckley, HB Gaspar, D Vetrie, S Tsukadab, JS Orange, M Stangel, M Berger, MM Eibl, J Kirmse, A Gardulf, ML Moore, H Milgrom, J Bayry, AG MacGregor, H Fujikawa, JF Van Impe, M Peleg, AS Perelson, WH Press, H Risken, MD Kazatchkine, T Tha-In, J Bayry, V Hurez, S Kaveri, P Aukrust, J Andersson, T Jungi, M Stangel, T Takai, N Prasad, MT Figge   +41 more
core   +1 more source

Assessment of the immunomodulatory properties of the probiotic strain Lactobacillus paracasei K5 in vitro and in vivo [PDF]

, 2020
Lactobacillus paracasei K5 is a lactic acid bacteria (LAB) strain that has been isolated from dairy products. Previous studies have established its probiotic potential in a series of in vitro tests, including molecular characterization, safety profiling,
Alexopoulos, Athanasios, Bezirtzoglou, Eugenia, Botaitis, Sotiris, Chondrou, Pelagia, Galanis, Alex, Karapetsas, Athanasios, Kiousi, Despoina Eugenia, Plessas, Stavros, Vasileiadis, Stavros, Ypsilantis, Petros   +9 more
core   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source