Results 111 to 120 of about 63,836 (336)

Optimizing jojoba oil methanolysis of cis‐13‐docosenol fatty alcohol to unveil its immunomodulatory potential: a circular biorefinery perspective

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The sustainable production of jojoba oil derivatives depends on research and development focused on eco‐friendly valorization processes. This study establishes optimal conditions for converting jojoba oil into jojobyl alcohols, which is a key step in realizing its economic potential.
Laura Mendoza‐García, Marcos Sánchez, Jorge Mario Marchetti, María Montoya   +3 more
wiley   +1 more source

A single centre phase II trial to assess the immunological activity of TroVax® plus pemetrexed/cisplatin in patients with malignant pleural mesothelioma – the SKOPOS trial

OncoImmunology, 2018
Vaccines in combination with chemotherapy have been shown to be safe in different tumor types. We investigated the immunological activity of the TroVax® vaccine in combination with pemetrexed-cisplatin chemotherapy in malignant pleural mesothelioma (MPM).
Jason F Lester, Angela C Casbard, Saly Al-Taei, Richard Harrop, Lajos Katona, Richard L Attanoos, Zsuzsanna Tabi, Gareth O Griffiths   +7 more
doaj   +1 more source

Adverse immunostimulation in early phase clinical trials: Key findings and recommendations based on the investigator's clinical experience

British Journal of Clinical Pharmacology, EarlyView.
Problem setting The emergence of therapeutic proteins has coincided with an increase of acute adverse immunostimulation (AIS). AIS has occured in clinical trials despite compliance with regulatory guidelines on preclinical evaluation and its incidence is anticipated to increase even further.
Juliette A. van den Noort, Marella C. E. van Ruissen, Lisanne C. A. Smidt, Naomi B. Klarenbeek, Philip H. K. Kremer, Manon A. A. Jansen, Jacobus Burggraaf, Joop M. A. van Gerven, Matthijs Moerland   +8 more
wiley   +1 more source

Unusual immunophenotype displayed by histiocytes in haemophagocytic lymphohistiocystosis. [PDF]

, 1987
Troels Herlin, Gorm Pallesen, Tom Kristensen, Niels Clausen   +3 more
openalex   +1 more source

Profiling a Neo‐Antigen‐Driven Immune Response in Healthy Volunteers: A Randomized, Double‐Blind, Placebo‐Controlled Study of the KLH Challenge Model

Clinical Pharmacology &Therapeutics, EarlyView.
Novel compounds targeting the adaptive immune system are commonly initially investigated in healthy volunteers (HV). HV frequently lack constitutively expressed drug‐target engagement biomarkers, complicating the evaluation of pharmacological activity. The keyhole limpet hemocyanin (KLH) neo‐antigen challenge elicits a controlled immune response in HV ...
Micha N. Ronner, Hendrika W. Grievink, Mahdi Saghari, Michelle Osse, Thierry P.P. van den Bosch, Jeffrey Damman, Marieke L. de Kam, Jacobus Burggraaf, Naomi B. Klarenbeek, Manon A. A. Jansen, Matthijs Moerland   +10 more
wiley   +1 more source

Canine lymphoma: a retrospective study (2009-2010) [PDF]

, 2012
This study reviews the medical records of 56 dogs diagnosed with lymphoma based on the cytological and/or histological results between January 1, 2009 and December 31, 2010.
Daminet, Sylvie, Mortier, Femke, Van de Maele, Isabel, Vandenabeele, Sophie   +3 more
core   +1 more source

Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology

Clinical Pharmacology &Therapeutics, EarlyView.
T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft, Sarah McFann, Alex Ferguson, Arthur Van De Vyver, Suzanne Gaudet, Eshita Khera, Jan‐Frederik Schlender   +6 more
wiley   +1 more source

CD4+ Th1 and Th17 responses and multifunctional CD8 T lymphocytes associated with cure or disease worsening in human visceral leishmaniasis

Frontiers in Immunology
IntroductionIn VL, a proinflammatory phenotype is typically associated with enhanced phagocytosis and a Th1 mediated immune response resulting in infection control.
Mariana Nobre Farias de Franca, Mariana Nobre Farias de Franca, Lorranny Santana Rodrigues, Lorranny Santana Rodrigues, Aline Silva Barreto, Aline Silva Barreto, Geydson Silveira da Cruz, Geydson Silveira da Cruz, José Carlos Aragão-Santos, José Carlos Aragão-Santos, Angela Maria da Silva, Angela Maria da Silva, Amélia Ribeiro de Jesus, Amélia Ribeiro de Jesus, Amélia Ribeiro de Jesus, Clarisa B. Palatnik-de-Sousa, Clarisa B. Palatnik-de-Sousa, Clarisa B. Palatnik-de-Sousa, Roque Pacheco de Almeida, Roque Pacheco de Almeida, Roque Pacheco de Almeida, Cristiane Bani Corrêa, Cristiane Bani Corrêa   +22 more
doaj   +1 more source

Determination of human platelet antigen frequencies in the Dutch population by immunophenotyping and DNA (allele-specific restriction enzyme) analysis [PDF]

, 1993
Suat Şimşek, NM Faber, P. M. M. Bleeker, AB Vlekke, Elly Huiskes, Roel Goldschmeding, AE von dem Borne   +6 more
openalex   +1 more source

Monitoring Treatment‐Associated Receptor Expression in Multiple Sclerosis Using a Newly Developed Panel for Spectral Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Multiple sclerosis (MS) is a chronic, immune‐mediated autoimmune disease characterized by the infiltration of autoreactive T cells and other inflammatory immune cells from the periphery into the central nervous system. Currently, there is no cure for MS, and treatment consists of disease‐modifying therapies (DMTs), most of which modify or ...
Katharina Robichon, Jennifer Taylor, Imogen Milner, Kathryn Elizabeth Hally, Anne Camille La Flamme   +4 more
wiley   +1 more source