Results 41 to 50 of about 58,168 (302)

Immunosuppressant nonadherence profile in kidney transplant recipients and the impact of medication adherence on transplant outcomes

Frontiers in Pharmacology
BackgroundDespite the fact that 1-year graft and recipient survival rates are above 90% in most transplant centers, improving long-term graft survival remains an important challenge.
Zou Zhi-yu, Zou Zhi-yu, Dai Lin-rui, Yu Chen-zhen, Chen Ren-jie, Yu Fei-hong, Chen Song, Chang Sheng, Zhang Wei-jie   +8 more
doaj   +1 more source

Post-Transplant Diabetes Mellitus in Renal Transplant Recipients, Single-Centre Data: Incidence, Risk Factors, and Effect on Graft Function and Mortality

Dubai Diabetes and Endocrinology Journal, 2023
Background: De novo post-transplant diabetes mellitus (PTDM) is a frequent complication among renal transplant recipients; it confers a high risk for graft failure and patient mortality.
Dileep Kumar, Kashif Gulzar, Fakhriya J. Alalawi, Ayman Aly Seddik, Hind Alnour, Maseer Ahmed, Sima Najad, Hussein Yousif, Mohamed Hussain Railey, Amna Khalifa Alhadari   +9 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Improved Health Outcomes in Patients with Systemic Lupus Erythematosus Following Early Belimumab Initiation Without Prior Immunosuppressant Use: A Real-World Descriptive Study

Rheumatology and Therapy
Introduction Patients with systemic lupus erythematosus (SLE) have variable treatment pathways, including antimalarials, glucocorticoids, immunosuppressants, and/or biologics.
Bernard Rubin, Yan Chen, Karen Worley, Brendan Rabideau, Benson Wu, Rose Chang, Maral DerSarkissian   +6 more
doaj   +1 more source

Microwave – assisted reduction of racemic intermediates potential immunosuppressant

Orbital: The Electronic Journal of Chemistry, 2012
Immunosuppressant are drugs that reduce the immune response, as important in the treatment of autoimmune diseases and rejection attenuators in organ transplants, the structural point of view generally have a high complexity.
Wender A. Silva, João V. Silva, Larissa G. Maciela, Lennine R. Melo, Júlia G. B. Pedreira, Guilherme R. Oliveira   +5 more
doaj   +1 more source

In vitro determination of the immunosuppressive effect, internalization, and release mechanism of squalene-gusperimus nanoparticles for managing inflammatory responses

Artificial Cells, Nanomedicine, and Biotechnology, 2021
Gusperimus is an anti-inflammatory drug that has shown to be effective in managing autoimmunity and preventing graft rejection. This is unstable and easily broken down into cytotoxic components.
Carlos E. Navarro Chica, Tian Qin, Bart J. de Haan, M.M Faas, Alexandra M. Smink, Ligia Sierra, Betty L. López, Paul de Vos   +7 more
doaj   +1 more source

Travel and immunosuppressant medication

, 2020
BACKGROUND: The use of potent immunosuppressant medications is becoming more common, particularly the use of biologicals for a range of conditions such as rheumatoid arthritis and inflammatory bowel disease.OBJECTIVE: This article focuses on the ...
Zwar, Nicholas A
core   +1 more source

Successful treatment of acquired amegakaryocytic thrombocytopenia with eltrombopag and immunosuppressant

, 2022
Acquired amegakaryocytic thrombocypenia (AAMT) is an extremely rare hematologic disorder and standard treatment strategy has not been established.
Ziqiang Yu, Danqing Kong, Depei Wu, Yun Li, Jie Yin, Hong Tian, Chengyuan Gu, Zhaoyue Wang   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, Volume 20, Issue 6, Page 1398-1419, June 2026.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Stopping of Mycophenolic Acid in Kidney Transplant Recipients for 2 Weeks Peri-Vaccination Does Not Increase Response to SARS-CoV-2 Vaccination—A Non-randomized, Controlled Pilot Study

Frontiers in Medicine, 2022
IntroductionKidney transplant recipients (KTR) are at high risk of developing severe COVID-19. However, vaccine response in this population is severely impaired with humoral response rates of 36–54 and 55–69% after two or three doses of SARS-COV-2 ...
Florina Regele, Andreas Heinzel, Karin Hu, Lukas Raab, Farsad Eskandary, Ingrid Faé, Sieglinde Zelzer, Georg A. Böhmig, Gregor Bond, Gottfried Fischer, Rainer Oberbauer, Roman Reindl-Schwaighofer   +11 more
doaj   +1 more source