Results 31 to 40 of about 61,557 (297)

A versatile toolkit for overcoming AAV immunity

Frontiers in Immunology, 2022
Recombinant adeno-associated virus (AAV) is a promising delivery vehicle for in vivo gene therapy and has been widely used in >200 clinical trials globally.
Xuefeng Li, Xuefeng Li, Xiaoli Wei, Jinduan Lin, Li Ou, Li Ou   +5 more
doaj   +1 more source

An Overview on the Nanoparticles-Based Optical Approaches for Determination of Immunosuppressant Pharmaceuticals [PDF]

ImmunoAnalysis
Immunosuppression is a crucial component of post-transplantation care in renal transplantation, as it helps to improve patient and graft survival rates.
Kader Poturcu, Elaf Mohamed Fauzi Osman, Abdalla Ahmed Elbashir   +2 more
doaj   +1 more source

Optimizing the use of nirmatrelvir/ritonavir in solid organ transplant recipients with COVID-19: A review of immunosuppressant adjustment strategies

Frontiers in Immunology, 2023
The coronavirus disease 2019 (COVID-19) pandemic has caused a significant burden of morbidity and mortality worldwide, with solid organ transplant recipients (SOTRs) being particularly vulnerable.
Yangming Tang, Yue Li, Turun Song
doaj   +1 more source

Contrasting treatment responses by Burkholderia cepacia complex-related deep pyoderma: A series of two cases [PDF]

Open Veterinary Journal, 2022
Background: The Burkholderia cepacia complex (Bcc) is an opportunistic pathogen in humans and animals. Deep pyoderma caused by these bacteria in dogs has been previously reported.
Yuki Shinomiya, Shingo Takagaki, Yoshiki Kawakami, Tomoki Motegi   +3 more
doaj   +1 more source

Treatment of active lupus nephritis with the novel immunosuppressant 15-deoxyspergualin : an open-label dose escalation study [PDF]

, 2011
Introduction: As the immunosuppressive potency of 15-deoxyspergualin (DSG) has been shown in the therapy of renal transplant rejection and Wegener's granulomatosis, the intention of this study was to evaluate the safety of DSG in the therapy of lupus ...
Hauser, Ingeborg A., Tesar, Vladimir, Heinzel, Peter A., Hiepe, Falk, Peter A Heinzel, Wilhelm H Schmitt, Vladimir Tesar, Ulf Müller-Ladner, Woehling, Heike, Nemoto, Kyuichi, Heike Woehling, Hanns-Martin Lorenz, Müller-Ladner, Ulf, Kyuichi Nemoto, Falk Hiepe, Lorenz, Hanns-Martin, Tarner, Ingo, Ingo Tarner, Tobias Alexander, Schmitt, Wilhelm H., Ingeborg A Hauser, Alexander, Tobias   +21 more
core   +1 more source

Real-world utilization patterns of systemic immunosuppressants among US adult patients with atopic dermatitis.

PLoS ONE, 2019
At the time of this study, prior to the introduction of biologics in the US, systemic therapies used for the treatment of moderate-to-severe atopic dermatitis included off-label immunosuppressants and corticosteroids.
April W Armstrong, Ahong Huang, Li Wang, Raymond Miao, Miraj Y Patel, Abhijit Gadkari, Usha G Mallya, Jingdong Chao   +7 more
doaj   +1 more source

An Immunosuppressive Tick Salivary Gland Protein DsCystatin Interferes With Toll-Like Receptor Signaling by Downregulating TRAF6

Frontiers in Immunology, 2018
Ticks, blood-feeding arthropods, and secrete immunosuppressive molecules that inhibit host immune responses and provide survival advantages to pathogens.
Ta Sun, Fanqi Wang, Wen Pan, Qihan Wu, Jingwen Wang, Jianfeng Dai   +5 more
doaj   +1 more source

Rheumatoid Meningitis Presenting With Acute Parkinsonism and Protracted Non-convulsive Seizures: An Unusual Case Presentation and Review of Treatment Strategies

Frontiers in Neurology, 2019
Rheumatoid meningitis is a rare complication of rheumatoid arthritis (RA). It is associated with substantial morbidity and mortality. The condition may present in a variety of ways and is therefore diagnostically challenging.
David Pellerin, Michael Wodkowski, Marie-Christine Guiot, Hisham AlDhukair, Hisham AlDhukair, Andrea Blotsky, Jason Karamchandani, Evelyne Vinet, Anne-Louise Lafontaine, Stuart Lubarsky, Stuart Lubarsky   +10 more
doaj   +1 more source

Macromolecular Immunosuppressants [PDF]

Biotechnology Journal, 2005
AbstractRecombinant immunosuppressants have come of age and represent a significant class of quite diverse drugs. They target extracellular molecules, and either label or inhibit them. Those targets are soluble factors or membrane proteins almost all of which are components of a very complex molecular network of communication and amplification. Notably,
Theo, Dingermann, Ilse, Zündorf
openaire   +2 more sources

Automated processing of whole blood samples for the determination of immunosuppressants by liquid chromatography tandem-mass spectrometry [PDF]

, 2006
Background: Liquid chromatography tandem-mass spectrometry (LC-MS/MS) is an efficient technology for routine determination of immunosuppressants in whole blood; however, time-consuming manual sample preparation remains a significant limitation of this ...
Spöhrer, Ute, Vogeser, Michael
core   +1 more source