Advanced Science, EarlyView.Brain diseases involve multilayered metabolic disruptions that reshape cellular interactions and microenvironments. This review outlines core metabolic features across disease states and presents emerging nanodelivery strategies as precision tools to reprogram pathological metabolism.
Jingyi Zhou, Chen Jiang
wiley +1 more source
Nanotechnology-based alternatives for the topical delivery of immunosuppressive agents in psoriasis. [PDF]
Int J Pharm, 2023 Gomes GS +5 more
europepmc +1 more source
IN VITRO IMMUNOSUPPRESSIVE EFFECTS OF CYTOTOXIC AGENTS CONJUGATED TO ANTIHUMAN LYMPHOCYTE GLOBULIN
, 1978 Henry Hirschberg +2 more
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HIFU‐Driven Targeted Pyroptosis Therapy in Basal‐Like Breast Cancer
Advanced Science, EarlyView.This study presents a HIFU‐driven pyroptosis strategy for BLBC treatment. Combining HIFU with platelet‐membrane hybridized liposomes encapsulating mitoxantrone enhances tumor targeting and efficacy. The synergistic treatment modulates key epigenetic regulators and activates the pyroptotic pathway through ROS generation and inflammasome signaling ...
Xiaomin Su +13 more
wiley +1 more source
Efficacy and Safety of Glucocorticoid Monotherapy Versus the Combination of Glucocorticoid and Immunosuppressive Agents for Immunoglobulin G4-Related Disease: A Systematic Review and Meta-Analysis. [PDF]
Cureus, 2023 Alsalamah NI +5 more
europepmc +1 more source
Effect of Antilymphocyte Serum and Other Immunosuppressive Agents on Canine Jejunal Allografts
, 1970 Mark A. Hardy, J Quint, David State
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Advanced Science, EarlyView.Glioblastoma (GBM) is the most aggressive primary brain tumor, with glioma stem cells (GSCs) driving treatment resistance. This study reveals that lactate promotes histone lactylation (H3K18la) at the VRK1 promoter, regulating GSC stemness and proliferation via the H3K18la/VRK1/YBX1/SOX2 pathway. The VRK1‐targeted nanoliposome A/TMZ‐siVRK1 demonstrates
Jinna Li +4 more
wiley +1 more source
Long-Term Use of Immunosuppressive Agents Increased the Risk of Fractures in Patients with Autoimmune Diseases: An 18-Year Population-Based Cohort Study. [PDF]
Biomedicines, 2023 Kao FC +5 more
europepmc +1 more source
IMMUNOSUPPRESSIVE AGENTS IN LUPUS NEPHRITIS: A CRITICAL ANALYSIS
, 1976 LUKE WAGNER
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