Results 131 to 140 of about 1,824,517 (243)

Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis. [PDF]

Front Immunol, 2023
Jiang N, Jin S, Yu C, Zhao J, Wang Q, Tian X, Li M, Zeng X.   +7 more
europepmc   +1 more source

Assessment of the inhibitory effect of immunosuppressive agents on rat T cell interferon-γ production using an ELISPOT assay

, 1991
The immunospot (ELISPOT) assay has proven to be an efficient and sensitive method for the enumeration of single cells secreting antibodies or cytokines.
Hermans, P., Labie, M.C.D.C. de, Kloosterman, T.C., Meide, P.H. van der, Olsson, T., Joosten, A.M.   +5 more
core  

An Intravesical Akkermansia muciniphila‐Based Chemo‐Immunotherapeutic Platform for Bladder Cancer

Advanced Science, EarlyView.
Pasteurized Akkermansia muciniphila is engineered into an intravesical F127/doxorubicin platform that couples localized chemotherapy with immune remodeling. By inducing apoptosis, ferroptosis, and immunogenic cell death, this chemo‐immunotherapeutic system enhances dendritic‐cell maturation, antigen cross‐presentation, and tumor‐specific CD8+ T‐cell ...
Rongkang Li, Anguo Zhao, Qi Zhuang, Lei Peng, Rui Liang, Jiadong Zhao, Yang Liu, Dashi Deng, Peng Yu, Xiqi Peng, Shaohua Zhang, Song Wu   +11 more
wiley   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

The new immunosuppressive era

, 1999
Immunosuppression, although necessary to enable the graft to escape the consequence of immune surveillance carries some risks for the patients. There is an associated increase in neoplasm, opportunistic infections, and end-organ toxicity.
Roth, D, Ciancio, G, Burke, G, Miller, J, Lo Monte, A I   +4 more
core   +2 more sources

Juvenile Dermatomyositis in Turkish Children

The Turkish Journal of Gastroenterology, 2011
Objectives: This study aims to determine the clinical features of juvenile dermatomyositis (JDM) in Turkish children. Patients and methods: The clinical records of nine children with JDM who were followed up in the Department of Pediatric Nephrology ...
Sebahat TÜLPAR, M. Hakan POYRAZOĞLU, Zübeyde GÜNDÜZ, Ruhan DÜŞÜNSEL, Funda BAŞTUĞ   +4 more
doaj  

Preparation of pyrido[3,2-d]pyrimidines as immunosuppressive agents

, 2008
This invention relates to substituted pyrido(3,2-d)pyrimidine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, pro-drugs and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly
Gao, Ling-Jie, Herdewijn, Piet, Dolusic, Eduard, De Jonghe, Steven, Pfleiderer, Wolfgang   +4 more
core  

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Insights on the role of anti-inflammatory and immunosuppressive agents in the amelioration of diabetes. [PDF]

Diabetol Int, 2023
Rai U, Senapati D, Arora MK.
europepmc   +1 more source