Results 151 to 160 of about 1,824,517 (243)

Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents. [PDF]

J Enzyme Inhib Med Chem, 2022
Walczak JM, Iwaszkiewicz-Grześ D, Ziomkowska M, Śliwka-Kaszyńska M, Daśko M, Trzonkowski P, Cholewiński G.   +6 more
europepmc   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Impact of pre-transplantation exposure to immunosuppressive agents on lung transplant outcomes in interstitial lung disease. [PDF]

Transpl Int
Tazibet K, Bunel V, Mal H, Goletto T, Halitim P, Morer L, Mouren D, Salpin M, Sandot A, Weisenburger G, Montravers P, Atchade E, Tanaka S, Frija J, Hajouji L, Castier Y, Mordant P, Crestani B, Borie R, El Husseini K.   +19 more
europepmc   +1 more source

Efficacy and Safety of Glucocorticoid Monotherapy Versus the Combination of Glucocorticoid and Immunosuppressive Agents for Immunoglobulin G4-Related Disease: A Systematic Review and Meta-Analysis. [PDF]

Cureus, 2023
Alsalamah NI, Alhrabi B, Alhumaily N, AlHadidi R, Basubrain LS, Al Asmari Z.   +5 more
europepmc   +1 more source

Multi‐Technique Integration Identifies O‐GlcNAc Transferase in Fibroblast‐Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis

Advanced Science, EarlyView.
AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie, Jie Huang, Chunhao Cao, Zhenchao Tang, Xingchen Li, Jianmin Guo, Xinxin Chen, Fang Wang, Dongyi He, Jie Li, Yu Du, Bing He, Jianhua Yao, Aiping Lu, Chao Liang   +14 more
wiley   +1 more source

TRAILblazing Astrocytes: Glioblastoma's Covert Immunosuppressive Agents. [PDF]

Neurosci Bull
Zhang JQ, Sun W, Jin WL.
europepmc   +1 more source

Statins in Kidney Transplant Recipients: Usage, All-Cause Mortality, and Interactions with Maintenance Immunosuppressive Agents. [PDF]

J Am Soc Nephrol, 2023
Bae S, Ahn JB, Joseph C, Whisler R, Schnitzler MA, Lentine KL, Kadosh BS, Segev DL, McAdams-DeMarco MA.   +8 more
europepmc   +1 more source

Cancer‐Associated Fibroblasts Promote Glucose Metabolic Reprogramming and Progression of Triple‐Negative Breast Cancer via Exosomal circFAD104‐Mediated Intercellular Communication

Advanced Science, EarlyView.
CAF‐derived exosomes deliver circFAD104 into TNBC cells, where it acts as a molecular scaffold that bridges the E3 ligase MARCHF8 and PGM1, promoting MARCHF8‐mediated K48‐linked ubiquitination and proteasomal degradation of PGM1. Loss of PGM1 redirects glucose‐phosphate flux from glycogen synthesis toward glycolysis, thereby driving stemness, EMT, and ...
Lei Wang, Xiaoyan Li, Yiran Liang, Yifei Wang, Yuhan Jin, Jianing Wang, Dan Luo, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Wenjing Zhao, Bing Chen, Lijuan Wang, Qifeng Yang   +16 more
wiley   +1 more source

Efficacy and safety of different immunosuppressive agents in patients with calcineurin inhibitor-dependent primary membranous nephropathy. [PDF]

Front Med (Lausanne)
Li Z, Cao S, Liang Z, Zhao F, Li K.
europepmc   +1 more source

A Case of Repeat Kidney Transplant Intolerant to Multiple First-line Immunosuppressive Agents Mycophenolate Mofetil, Azathioprine, and Calcineurin Inhibitors

A repeat kidney transplant is the preferred treatment for graft failure due to its enhanced survival benefits and improved quality of life, despite facing greater medical, immunological, and surgical challenges compared to the first transplant ...
Tarique Naseem, Rajan Duggal, Puneet Arora, Deepak Garg   +3 more
core   +1 more source