Results 151 to 160 of about 735,523 (289)

Cancer Immunotherapy: Facts and Fancy [PDF]

, 1979
E. Benjamini, D Rennick
openalex   +1 more source

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis

Advanced Healthcare Materials, EarlyView.
This review highlights the potential of organ‐on‐a‐chip systems for studying comorbidities, using chronic kidney disease (CKD) and osteoarthritis (OA) as examples. It summarizes recent advances in kidney‐on‐a‐chip and joint‐on‐a‐chip models and discusses their current and potential application in investigating CKD, OA, and CKD‐OA comorbidity, aiming to
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran, Ruoxiao Xie   +7 more
wiley   +1 more source

TGF-β Decreases NK Cell Mobility and Cytotoxic Efficacy in Complex in vitro Models of the Leukemia Microenvironment

ImmunoTargets and Therapy
Veronika Švubová,1,2 Lucie Janstová,1 Marek Jedlička,1,2 Eva Mašínová,1,2 Jana Szabová,1 Tereza Feglarová,1 Kateřina Kuglerová,1 Veronika Bosáková,3,4 Barbora Brodská,1 Kristýna Boráková,5 David Kundrát,1 Iva Trsová,1,6 Martina ...
Švubová V, Janstová L, Jedlička M, Mašínová E, Szabová J, Feglarová T, Kuglerová K, Bosáková V, Brodská B, Boráková K, Kundrát D, Trsová I, Böhmová M, Kuželová K, Hrdý J, Gašová Z, Vydra J, Dostálová Merkerová M, Hortová-Kohoutková M, Frič J   +19 more
doaj  

Characterization of alternative sPD-1 isoforms reveals that ECD sPD-1 signature predicts an efficient antitumor response

Communications Biology
Soluble PD-1 is a dissociated form of membrane PD-1 broadly present in cancer, infections, or autoimmune diseases. However, the clinical significance of sPD-1 remains controversial due to the uncertainty of its isoforms, origin, and production mechanism.
Ping Hou, Li Hu, Junrong Zhang, Xiaoyan Zhou, Yonglei Xiao, Lijun Li, Qiongwen Wu, Jing Liu, Yuhong Lin, Ling Chen   +9 more
doaj   +1 more source

Nanobody‐Decorated Lipid Nanoparticles for Enhanced mRNA Delivery to Tumors In Vivo

Advanced Healthcare Materials, EarlyView.
This study presents a targeted mRNA‐LNP platform engineered with anti‐PSMA nanobodies for prostate cancer therapy. Using different in vivo models, the authors demonstrate selective uptake and mRNA delivery in PSMA+ cancer cells. However, while targeting is enhanced, mRNA delivery efficacy is limited by tissue penetration, tumor necrosis, and immune ...
Pol Escudé Martinez de Castilla, Vincenzo Verdi, Willemijn de Voogt, Mariona Estapé Sentí, Arnold C. Koekman, Julian Rietveld, Sven van Kempen, Qiangbing Yang, Juliette van Merris, Guido Jenster, Martin E. van Royen, Marcel H. Fens, Sander A. A. Kooijmans, Wytske M. van Weerden, Guillaume van Niel, Pieter Vader, Raymond M. Schiffelers   +16 more
wiley   +1 more source

Specific Active Immunotherapy for Melanoma

, 1979
Hilliard F. Seigler, Edwin B. Cox, F Mutzner, L. E. Shepherd, Emma Nicholson, William W. Shingleton   +5 more
openalex   +2 more sources

DISCUSSION PAPER: MODALITIES OF IMMUNOTHERAPY FOR VIRALLY INDUCED MURINE NEOPLASMS* [PDF]

, 1976
Joseph G. Sinkovics
openalex   +1 more source

Multifunctional Biomedical Devices with Closed‐Loop Systems for Precision Therapy

Advanced Healthcare Materials, EarlyView.
This review explores two major types of closed‐loop therapeutic systems: self‐sustained and externally triggered. It highlights recent advances in stimuli‐responsive materials, integrated bioelectronics, and data‐driven control strategies, offering insight into emerging strategies for personalized, responsive drug delivery.
Yixuan Leng, Rujie Sun
wiley   +1 more source

Immunotherapy of the Dunning Leukaemia with Thymic Extracts

, 1973
Ban An Khaw, Antony Rule
openalex   +2 more sources

Rolling Ultrasharp Microneedle Spheres Enable Topical Delivery of Biologics Through the Skin

Advanced Healthcare Materials, EarlyView.
Rolling ultraminiaturized microneedle spheres (RUMS), created via two‐photon polymerization, unlock effective and painless topical delivery of messenger RNA (mRNA) and drugs through the skin. By gently forming thousands of microscopic pores, RUMS boost skin permeability by up to 100‐fold.
Theocharis Nikiforos Iordanidis, Argyris Spyrou, Samantha Roudi, Fredrik J. Swartling, Göran Stemme, Samir EL Andaloussi, Niclas Roxhed   +6 more
wiley   +1 more source