Results 41 to 50 of about 314,880 (255)
MORC3 represses a tandem repeat enhancer to regulate interferon
The EMBO JournalThe antiviral protein MORC3 is frequently inhibited by viruses. To counteract viral antagonism, MORC3 represses a noncanonical pathway of type-I-interferon (IFN) such that viral inhibition of MORC3 triggers ( > 10,000-fold) IFN induction.
Luisa Krumwiede +13 more
doaj +1 more source
FEBS Open Bio, EarlyView.The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley +1 more source
McsB forms a gated kinase chamber to mark aberrant bacterial proteins for degradation
eLife, 2021 In Gram-positive bacteria, the McsB protein arginine kinase is central to protein quality control, labeling aberrant molecules for degradation by the ClpCP protease.
Bence Hajdusits +7 more
doaj +1 more source
IMP-1002 treatment during schizogony changes the differential solubility of ARO and CDPK1.
, 2021 To examine the differential solubility of proteins present in IMP-1002–treated and untreated parasites, Percoll-purified schizonts were lysed and sequentially fractionated using hypotonic and high salt buffers (to solubilize cytoplasmic proteins), sodium
Philip Hobson (204485) +11 more
core +1 more source
Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird +9 more
wiley +1 more source
Structure of the human core transcription-export complex reveals a hub for multivalent interactions
eLife, 2020 The export of mRNA from nucleus to cytoplasm requires the conserved and essential transcription and export (TREX) complex (THO–UAP56/DDX39B–ALYREF). TREX selectively binds mRNA maturation marks and licenses mRNA for nuclear export by loading the export ...
Thomas Pühringer +6 more
doaj +1 more source
ACTRIS IMP Deliverable 3.1: Draft Innovation Strategy
, 2021 This document is prepared in the context of the activities of the ACTRIS IMP project, in particular in Work Package 3 which provides strategic guidance and steering to enhance the relevance of ACTRIS to science, innovation and society, and monitors the ...
Häme, Silja +8 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau +11 more
wiley +1 more source
An interpretable machine learning system for colorectal cancer diagnosis from pathology slides
npj Precision OncologyConsidering the profound transformation affecting pathology practice, we aimed to develop a scalable artificial intelligence (AI) system to diagnose colorectal cancer from whole-slide images (WSI).
Pedro C. Neto +12 more
doaj +1 more source
Digital Pathology Implementation in Private Practice: Specific Challenges and Opportunities
Diagnostics, 2022 Digital pathology (DP) is being deployed in many pathology laboratories, but most reported experiences refer to public health facilities. In this paper, we report our experience in DP transition at a high-volume private laboratory, addressing the main ...
Diana Montezuma +7 more
doaj +1 more source