Results 91 to 100 of about 37,251,550 (358)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Annual IMPACT report 2017: A report by the IMPACT data collection and analysis team [PDF]
, 2017 This is the 2017 annual report of Instruction Matters: Purdue Academic Course Transformation (IMPACT). IMPACT was created in 2010, and is a large collaborative initiative on the Purdue West Lafayette campus involving multiple key partners across campus ...
IMPACT Management Team, +1 more
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Life cycle impact assessment based on decision analysis [PDF]
, 2003 Life cycle assessment (LCA) is a popular tool for evaluating environmental impacts of products and services. However, the methodological choices and framework to assess environmental impacts in LCA are still under discussion.
Seppälä, Jyri
core
Nordic overturning increases as AMOC weakens in response to global warming [PDF]
Ocean ScienceThe Atlantic Meridional Overturning Circulation (AMOC) is weakening in response to global warming, while the Nordic Seas Overturning Circulation (NOC) is projected to strengthen.
S. Roewer +7 more
doaj +1 more source
The impact of obesity on esophagectomy: a meta-analysis [PDF]
Diseases of the Esophagus, 2017 The impact of body mass index (BMI) on postoperative outcomes after curative resection for esophageal cancer has been assessed in many studies worldwide with conflicting conclusions. The aim of this meta-analysis is to evaluate the influence of preoperative BMI on surgical and oncologic outcomes after radical surgery for esophageal cancer, in Western ...
Mengardo V. +4 more
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Value of a community football club [PDF]
, 2015 Research background The Centre for Sport and Social Impact (CSSI) at La Trobe University was commissioned by AFL Victoria to determine the social value of a \u27typical\u27 community football club; specifically its social, health and community impact ...
Centre for Sport and Social Impact (LaTrobe)
core
Genomic Sequencing Procedure Microcosting Analysis and Health Economic Cost-Impact Analysis
Journal of Molecular Diagnostics, 2016 The increasing use of advanced nucleic acid sequencing technologies for clinical diagnostics and therapeutics has made vital understanding the costs of performing these procedures and their value to patients, providers, and payers.
L. Sabatini +7 more
semanticscholar +1 more source
American Journal of Preventive Medicine, 2020 Introduction Because of their inability to access adequate medical care, transportation, and nutrition, socially vulnerable populations are at an increased risk of health challenges during disasters.
I. Karaye, J. Horney
semanticscholar +1 more source