Results 81 to 90 of about 13,192,083 (308)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Combined effects of climate and land-use change on the provision of ecosystem services in rice agro-ecosystems

Environmental Research Letters, 2017
Irrigated rice croplands are among the world’s most important agro-ecosystems. They provide food for more than 3.5 billion people and a range of other ecosystem services (ESS).
Fanny Langerwisch, Tomáš Václavík, Werner von Bloh, Tobias Vetter, Kirsten Thonicke   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Timing of a future glaciation in view of anthropogenic climate change

Communications Earth & Environment
Human activities are expected to delay the next glacial inception because of the long atmospheric lifetime of anthropogenic CO2. Here we present Earth system model simulations for the next 200,000 years with dynamic ice sheets and interactive atmospheric
Christine Kaufhold, Matteo Willeit, Guy Munhoven, Volker Klemann, Andrey Ganopolski   +4 more
doaj   +1 more source

Schools, Taxes and the New York Economy: An Economic Analysis of a Balanced Budget Alternative to the Governor's School Aid Cuts [PDF]

, 2003
A first-ever analysis of the economic impact of Governor Pataki's proposed school aid cuts shows that those cuts are "job killers." Restoring those cuts, even after taking into consideration the offsetting impact of an income tax increase to fund them ...

core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The relationship between feeding practices and stunting among children under two years in Tanzania mainland: a mixed-method approach

Bulletin of the National Research Centre
Background Proper infant and young child feeding practices have gained attention over the years as one of the interventions to reduce childhood stunting.
Faith Mandara, Charles Festo, Erick Killel, Samwel Lwambura, Jackline Mrema, Farida Katunzi, Haikael D. Martin, Ester Elisaria   +7 more
doaj   +1 more source

A Racial Impact Analysis of HB 994: Human Trafficking [PDF]

, 2014
Human Trafficking has become an international crisis that has caused a devastating impact on the Commonwealth of Virginia. The purpose of this report is to examine the racial equity impact of Virginia House Bill 944. HB 994 was introduced to the House by
Boone, Staci, DeShazor, Traci, Grace E. Harris Leadership Institute, Virginia Commonwealth University, Miles, Selonia, Williams, Katina   +4 more
core   +1 more source