Results 161 to 170 of about 13,806,711 (306)

Impact Assessment of Induced System Faults on the Performance of Natural Gas Engines. [PDF]

ACS Omega
Xu H, Sun R, Lyu Y, Gu Y, Liu Q, Li Z, Jia Z, Zeng Z, Chen G.   +8 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Flows of Knowledge: A Method for Impact Assessment

The Flows of Knowledge evaluation method, as introduced by Meagher, Lyall and Nutley (2008) and described in Edwards and Meagher (2020), provides a framework for assessing the impacts of scientific research on policy and practice.
Evaluating Societal Impact
core   +1 more source

Pilot implementation of 'outsourced oxygen to the bedside' models in five countries: a mixed methods impact assessment. [PDF]

BMJ Public Health
Kitutu FE, Blaas C, Mukisa P, Schedwin M, Baker T, Bakare AA, Bishit D, Mkumbo E, Oliwa J, Namasopo S, Nzinga J, Raune M, Adeniji A, Hawkes MT, Rai A, Njuguna M, Graham HR, King C.   +17 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Burden of cancer attributable to six occupational exposures in the Netherlands, 2021: a health impact assessment study. [PDF]

BMJ Public Health
De Crom TOE, Eekhout I, Lebbink E, Lanting C, Peters S, Pronk A, Ge C.   +6 more
europepmc   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

A Unified Life Cycle Impact Assessment Framework for Global Terrestrial Biodiversity Decline. [PDF]

Environ Sci Technol
Janssen SD, Kuipers KJJ, Moreira H, Schipper AM, van Zelm R, Huijbregts MAJ.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source