Results 241 to 250 of about 2,638,873 (305)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Treatment of Challenging Behaviour in Children and Youth With an Intellectual Disability With or Without Autism. [PDF]

J Appl Res Intellect Disabil
Magnacca C, Carrier C, Esteves J, Perry A.   +3 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Navigating care together: developing a collaborative checklist to improve care for children with intellectual disabilities. [PDF]

Res Involv Engagem
Trower HL, Oliver C, Bull LE, Garstang JJ, Gray KM, Hanna H, Harvey K, Liew A, Muller S, McDonald S, Krupinski C, Crawford H.   +11 more
europepmc   +1 more source

The prevalence of autism spectrum traits and autism spectrum disorders in children and adolescents with obsessive compulsive disorder: systematic review and meta-analysis. [PDF]

BJPsych Open
Tiley C, Lampropoulou P, Samara M, Kyriakopoulos M.   +3 more
europepmc   +1 more source

Systematic evaluation of commercially available pain-management mHealth apps for chronic pain in the United Kingdom. [PDF]

Br J Health Psychol
Harding RP, Gillett JL, Passaportis M, Miles E, Matcham F.   +4 more
europepmc   +1 more source

Plating larval zebrafish prior to the day of experimentation has no impact on spontaneous swimming and startle responses. [PDF]

MethodsX
Harper MMM, Hagen EV, Zhang Y, Hamilton TJ.   +3 more
europepmc   +1 more source

Adherence to handwashing behaviour and its impact on the incidence and death of viral respiratory infectious diseases: a systematic review, meta-analysis and modelling study. [PDF]

BMJ Glob Health
Zhou W, Chen C, Qi J, Chen M, Yuan Z, Miao J, Chen J, Jiang D, Yang M, Du Y, Cao K, Wu X, You Y, Chen D, Qu R, Yang S.   +15 more
europepmc   +1 more source