Results 71 to 80 of about 14,048,705 (249)

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Promotion of Efficient Use of Energy: Final Report

open access: yes, 2006
The Department of Energy funded the Alliance to Save Energy to promote the efficient use of energy under a multiyear cooperative agreement. This funding allowed the Alliance to be innovative and flexible in its program development, and to initiate and ...
Alliance to Save Energy (U.S.)
core   +1 more source

Weldability investigation on real welded plates of fine-grained high-strength steel S960QL

open access: yesMetalurgija, 2017
The paper presents results of impact energy effects on real welded specimens of fine-grained high-strength S960QL steel, and elaborates the dependence of real welded specimen hardness on heat input.
I. Samardžić   +3 more
doaj  

Environmental co-benefits and adverse side-effects of alternative power sector decarbonization strategies

open access: yesNature Communications, 2019
There lacks a consistent and holistic evaluation of co-benefits of different mitigation pathways in studies on Integrated Assessment Models. Here the authors quantify environmental co-benefits and adverse side-effects of a portfolio of alternative power ...
Gunnar Luderer   +16 more
doaj   +1 more source

Performance Assessment of a Developed Brake Frame Based on the Application of a Proposed Equivalent Model in a Net Protection System for Debris Flow

open access: yesApplied Sciences, 2018
The demand for a net protection system for mitigating debris flow has increased recently for which new energy absorption devices have been hereby developed. The purpose of this study is to analyze the behavior and energy absorption rate of a brake frame,
Sungtae Kim   +3 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Impact Strategy Development Toolkit

open access: yes
This tool outlines the process and useful tools for developing school-level impact strategies. It guides you through the strategy development journey, from the initial preparatory activities to the evaluation.
Evaluating Societal Impact
core   +1 more source

Evaluation of the impact energy of the samples produced by the additive manufacturing technology

open access: yesMetalurgija, 2016
The article covered the evaluation of the impact energy, notch toughness and morphology of the fracture surfaces of the specimens manufactured by the Direct Metal Laser Sintering Technology.
J. Dobránsky   +6 more
doaj  

Experimental investigations on the compaction energy for a robotic rammed earth process

open access: yesFrontiers in Built Environment
Rammed earth is a construction material with a long history of traditional manufacturing. Due to its low environmental impact, positive impact on indoor climate and completely recyclable nature, its demand is also increasing in modern construction ...
Linus Paul Schmitz   +5 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

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