Results 71 to 80 of about 597,802 (215)
The Influence of Mechanical Impact on the Dynamic Response of Multibody Systems
MathematicsContact–impact phenomena caused by joint clearances can significantly alter the dynamic response of high-speed mechanical systems, yet fewer studies combine analytical impact-force modeling, virtual prototyping, and experimental observations for multi ...
Sorin Dumitru +6 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Dynamic Response and Mechanism Study Under Impact–Corrosion Coupling Effects
BuildingsOffshore reinforced concrete (RC) structures, such as bridges and high-piled wharves, are frequently subjected to the coupled action of steel corrosion and ship collision loads.
Xinping Li +5 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Study of elastoplastic deformations in the dynamic interaction of two rigid deformable bodies
Омский научный вестникThe article is a continuation of the study of dynamic dependencies between force and depth of introduction of conical indenters into barriers. The indenter is a cylinder with a pointed conical part. Indenters and barriers are made of steel.
D. I. Chernyavsky
doaj +1 more source
Iterative-Based Impact Force Identification on a Bridge Concrete Deck. [PDF]
Sensors (Basel), 2023 Rashidi M +4 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Macroscopic fracture mechanism of coal body and evolution characteristics analysis of impact force in deep coal and gas outburst. [PDF]
Sci Rep, 2023 Ren L, Tang J, Pan Y, Zhang X, Yu H.
europepmc +1 more source