Results 61 to 70 of about 5,630 (304)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Pengaruh Pengalaman Auditor, Profesionalisme Auditor, Task Complexity, Time Pressure, Gender dan Etika Profesi Terhadap Auditor Materiality Judgments (DKI Jakarta, Indonesia)

Jurnal Akuntansi: Kajian Ilmiah Akuntansi
Public Accounting Firms are professional institutions that are obliged to uphold ethics and professionalism, and are capable of global competition on an international and national scale.
Rudi Ginting
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Exploring companies' relationships with environmental indicators from the European sustainability reporting standards (ESRS) – The case of NorwayMendeley Data

Current Research in Environmental Sustainability
The Corporate Sustainability Reporting Directive (CSRD) marks a major shift in EU sustainability reporting by requiring compliance with the European Sustainability Reporting Standards (ESRS). This study examines how a sample of Norwegian companies relate
Jørgen Kjøsen Lindgren, Adrian Tobias Werner, Nora Johanne Klungseth, Bjørn Sørskot Andersen   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Impact of Stereo- and Regiochemistry on Energetic Materials

Journal of the American Chemical Society, 2019
The synthesis, physical properties, and calculated performances of six stereo- and regioisomeric cyclobutane nitric ester materials are described. While the calculated performances of these isomers, as expected, were similar, their physical properties were found to be extremely different.
Lisa M. Barton, Jacob T. Edwards, Eric C. Johnson, Eric J. Bukowski, Rosario C. Sausa, Edward F. C. Byrd, Joshua A. Orlicki, Jesse J. Sabatini, Phil S. Baran   +8 more
openaire   +3 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Materializing the blue economy: tuna fisheries and the theory of access in the Western Indian Ocean

Journal of Political Ecology, 2019
Many African countries are progressively embracing the blue economy. African islands of the western Indian Ocean, however, have been involved in it for more than twenty years through the exploitation of their 'blue gold': tuna.
Mialy Andriamahefazafy, Christian A. Kull   +1 more
doaj   +1 more source

Impact. Slow Impact Punching in Brittle Materials.

Journal of the Society of Materials Science, Japan, 1996
In order to develop an impact punching technique in brittle materials, slow impact punching tests were carried out in a soda lime glass and some engineering ceramics by using a specially designed clamping device made of a frame and a compact powerful jack.
SAKAGUCHI, Ken-ichi, NOJIMA, Taketoshi
openaire   +2 more sources