Results 71 to 80 of about 5,630 (304)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Review of studies on elements of materiality in sustainability assurance in corporate reporting
Accounting and Management ResearchIn the current context, where corporate sustainability is increasingly relevant, understanding the elements of Materiality and their impact on sustainability assurance is essential.
Miseldra Gil-Marín +4 more
doaj +1 more source
Research on the Role of Media Materiality and Data-Driven Survival in the Context of Embodied Communication [PDF]
SHS Web of ConferencesFrom an embodied communication perspective, research on media materiality and data-driven survival focuses on how human interaction and existence can be understood through the physical forms of media technologies and data flows.
Ren Xuanying
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Materiality definition, reporting regime, and sustainability disclosure
The trend of companies issuing sustainability reports is on the rise. However, the materiality of sustainability information continues to be a topic of much debate. I experimentally examine how different materiality definitions (financial materiality vs.
Cai, Qingzhi
core +1 more source
PROFESSIONAL JUDGEMENT OF AN ACCOUNTANT WHILE CHOOSING THE CRITERIA OF MATERIALITY
Учёт. Анализ. Аудит, 2019 The development of the accounting system is accompanied by an increase in the number of situations, when the facts of economic activities are reflected depending on judgments, especially on the criteria of materiality.The article considers two groups of ...
VALENTINA Sitnikova
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The materiality of political jurisprudence
, 2016 Political jurisprudence provides a reconstruction of the enabling conditions of public law and a methodology for the study of its meaning. This article offers a critical appraisal of political jurisprudence by understanding this approach as a further ...
Goldoni, Marco
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