Results 41 to 50 of about 9,216,494 (260)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Modeling and Mitigation of Noise on the A23 Motorway Using GIS

Proceedings, 2018
Rendering at the European Directive 2002/49/EC, all EU members have to draw up a strategic noise map for all agglomerations with more than 250,000 inhabitants and for all major airports, roads and railways.
António Carvalho, Victor Cavaleiro, António Albuquerque, Flora Silva   +3 more
doaj   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

STUDY ON THE PHONIC POLLUTION DUE TO MINING ACTIVITIES IN LIGNIT CAREERS [PDF]

Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2018
The environmental impact of coal exploitation is significant, inevitable and irreversible, with effects on aquatic systems, air, natural mineral resources, ecosystems, climate, geomorphology and landscape, land use and human collectivity.
Nicoleta-Maria Mihuţ , Adina Milena Tatar   +1 more
doaj  

Cochlear Damage Caused by the Striking Noise of Titanium Head Golf Driver [PDF]

Clinical and Experimental Otorhinolaryngology, 2019
Objectives. To investigate how mouse cochleae are affected by the striking noise of titanium head golf driver. Methods. Thirty-two BALB/c mice (20–22 g) with normal hearing were used.
Yong-Ho Park, Juyong Chung, Min Young Lee, Doh Young Lee, Young Ho Kim   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A before–after control–impact assessment to understand the potential impacts of highway construction noise and activity on an endangered songbird

Ecology and Evolution, 2017
Anthropogenic noise associated with highway construction and operation can have individual‐ and population‐level consequences for wildlife (e.g., reduced densities, decreased reproductive success, behavioral changes).
Ashley M. Long, Melanie R. Colón, Jessica L. Bosman, Dianne H. Robinson, Hannah L. Pruett, Tiffany M. McFarland, Heather A. Mathewson, Joseph M. Szewczak, J. Cal Newnam, Michael L. Morrison   +9 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

THE DAMANGING COMPONENT NOISE OF THE ENVIROMENT PRESENT POLLUTION [PDF]

Analele Universităţii "Constantin Brâncuşi" din Târgu Jiu: Seria Inginerie, 2019
In contrast to many other environmental problems, noise pollution continues to increase thanks to industrial, social and transportation field development. The paper analyze specific aspects on the impacts of noise on health.
Emilia Simona Mocanu (Irod)
doaj