Results 141 to 150 of about 1,241,285 (268)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Investigation of the Reinforcement Mechanism and Impact Resistance of Carbon Hollow Microsphere-Reinforced PDMS Composites. [PDF]

Polymers (Basel)
Yu Y, Zhang Y, Yang C, Meng F, Meng F, Wang T, Luo Z.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

The Impact of Pipeline Resistance [PDF]

, 2021
openaire   +1 more source

Experimental investigation on impact resistance of stacked composite material hybridization by 3D printed CF-PEEK and aluminium foils. [PDF]

Sci Rep
Sado MK, Zainuddin S, Aljabri A, Badruddin IA, Petrů J, Bashir MN, Kamangar S, Ahmed GMS, Javali MA.   +8 more
europepmc   +1 more source

Research on the comparison of impact resistance characteristics between energy absorption and conventional hydraulic columns in fluid-solid coupling. [PDF]

Sci Rep, 2023
Zhang J, Guo H, Xiao Y, Pan Y, Xu K, Guo C, Ni B, Zhao F.   +7 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Impact Resistance Behaviors of Carbon Fiber Fabric Reinforced Composite Laminates with Bio-Inspired Helicoidal Layups. [PDF]

Biomimetics (Basel)
Du L, Tang J, Wang Z, Zhou J, Xiong X, Li X, Chen M.   +6 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

In-situ localised alignment assisted salting-out enhanced ionogels with high strength, toughness and impact resistance. [PDF]

Nat Commun
Zhang Z, Sang M, Li Z, Pan Y, Wu J, Duan S, Gong X.   +6 more
europepmc   +1 more source