Results 181 to 190 of about 3,311,310 (295)

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Enhanced impact resistance of novel sustainable preplaced aggregate geopolymer concrete reinforced with steel mesh and 5D fibers. [PDF]

Sci Rep
Samadi M, Murali G, Wong LS, Kurpińska M, Abdelgader HS, Abdulkadir I, Lim NHAS, Avudaiappan S, Abdellatief M.   +8 more
europepmc   +1 more source

Analysis of the Impact Resistance of Toecaps by the Finite Element Method: Preliminary Studies. [PDF]

Int J Environ Res Public Health, 2022
Kropidłowska P, Irzmańska E, Gołębiowski Ł, Jurczyk-Kowalska M, Boczkowska A.   +4 more
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mechanisms Underpinning Dynamic Impact Resistance Reinforcement by Multi-Scale Synergistic Effect Through Nano-Silica and Carbon Hollow Microsphere. [PDF]

Polymers (Basel)
Yu Y, Yang C, Zhang Y, Wang L, Wang H, Meng F, Meng F, Wang T, Luo Z.   +8 more
europepmc   +1 more source

Low-Velocity Impact Resistance of 3D Re-Entrant Honeycomb Sandwich Structures with CFRP Face Sheets. [PDF]

Polymers (Basel), 2023
Cui Z, Qi J, Duan Y, Tie Y, Zheng Y, Yang J, Li C.   +6 more
europepmc   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Effects of Stacking Configuration on Impact Resistance of Electric Locomotive Coupling Protective Covers Reinforced by CFRP, GFRP, and Their Hybrids. [PDF]

Materials (Basel)
Xu Y, Chen J, Guan M, Xiao S, Yang G, Chen D.   +5 more
europepmc   +1 more source

Coupled Effect of Polypropylene Fibers and Slag on the Impact Resistance and Mechanical Properties of Concrete. [PDF]

Materials (Basel), 2022
Ali AB, Sharif MB, Irfan-Ul-Hassan M, Iqbal Y, Akmal U, Alabduljabbar H, Deifalla AF.   +6 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source