Results 71 to 80 of about 25,604,119 (393)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Molecular parameters of post impact cooling in the Boltysh impact structure [PDF]
, 2010 Impact events have the potential to generate a number of long-term sources of heat that can lead to the initiation of hydrothermal systems when the impact occurs on a water- or ice-rich target.
Gilmour, I. +5 more
core
Vibration, 2021 This paper presents the identification of both location and magnitude of impact forces applied on different positions of a multi-storey tower structure using different types of transducers, i.e., an accelerometer, a laser Doppler vibrometer, and a ...
Hamed Kalhori +2 more
doaj +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Recent progress of geophysical exploration in Earth's impact craters
地球与行星物理论评Geophysical exploration plays an important role in detecting and studying impact structures. This article reviews the common geophysical features of Earth's impact craters, including their gravity, magnetic, electrical, and seismic characteristics.
Yangfan Deng +6 more
doaj +1 more source
Research on Dynamic Characteristics of Canopy and Column of Hydraulic Support under Impact Load
Energies, 2022 In the process of coal mining, the canopy and column play an important role in the safety support of hydraulic support. However, due to the complex and changeable coal seam conditions, the hydraulic support is significantly affected by the impact load ...
Qingliang Zeng +4 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Impact characterisation of doubly curved composite structure [PDF]
, 2009 Under repeated impact composite domes subjected 6 J energy, changes locally with increasing drop height. The action of the dynamic load generates reactions at the support and bending moments at points on the surface of the composite.
Banks, W.M. +2 more
core
The Functional Impact of Mitochondrial Structure Across Subcellular Scales
Frontiers in Physiology, 2020 Mitochondria are key determinants of cellular health. However, the functional role of mitochondria varies from cell to cell depending on the relative demands for energy distribution, metabolite biosynthesis, and/or signaling.
B. Glancy +4 more
semanticscholar +1 more source
Quantifying the Impact of Structural Reforms [PDF]
SSRN Electronic Journal, 2006 We estimate a dynamic, intertemporal optimisation model that mimics features of European labour markets, such as sticky nominal wages and sluggish adjustment of employment to shocks for 15 OECD countries. The estimates include a measure for the degree of labour market sluggishness that compares well with standard indicators of product and labour market
Ernst, Ekkehard +3 more
openaire +3 more sources