Results 141 to 150 of about 36,786,045 (343)

Enhanced Computational Biased Proportional Navigation with Neural Networks for Impact Time Control

Aerospace
Advanced computational methods are being applied to address traditional guidance problems, yet research is still ongoing regarding how to utilize them effectively and scientifically.
Xue Zhang, Haichao Hong
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

The Impact of Biseasonal Time Changes on Migraine

Neurology International
Background: Changes in the daily rhythm can trigger migraine attacks. The sensitivity for triggering attacks is closely linked to the regulation of biological rhythms controlled by the hypothalamus.
Carl H. Göbel, Katja Heinze-Kuhn, Axel Heinze, Anna Cirkel, Hartmut Göbel   +4 more
doaj   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Impact of Screen Time on Development of Children

Children
Background: Children today are growing up in a digital environment where screen-based technology is a central part of everyday life. While screens can offer educational and recreational benefits, there is growing concern about their influence on ...
Subhranshu Sekhar Kar, Rajani Dube, Bellary Kuruba Manjunatha Goud, Qonitah Syadida Gibrata, Adlen Adnan El-Balbissi, Tasnimm Ahmad Al Salim, Rand Nedal Mohammad Al Khaled Fatayerji   +6 more
doaj   +1 more source

Reliability and Test Differences for the Impact: Implications for Concussion Testing Programs

, 2019
This study was conducted to determine the long-term relatability of ImPACT scores among young athletes. Youth sport participants (n=294) who completed ImPACT tests one year apart were included in the study.
Koch, Christopher, Robertson, Sean
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Time Poverty and its Impact on Research Culture

Exchanges
This article, based on our experience carrying out research culture surveys at our respective universities, discusses how ‘time poverty’ represents a significant challenge to the creation of positive research cultures.
Karin Wahl-Jorgensen, Candy Rowe
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source