Results 111 to 120 of about 2,037,826 (341)

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

open access: yesFEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Impact resistance of current design composite fan blades tested under short-haul operating conditions [PDF]

open access: yes
Boron/epoxy and graphite/epoxy composite blades were impacted in a rotating whirligig facility with conditions closely simulating those which might be experienced by a STOL engine impacted with various foreign objects.
Salemme, C. T., Steinhagen, C. A.
core   +1 more source

The impact of impact studies [PDF]

open access: yesHelgoländer Wissenschaftliche Meeresuntersuchungen, 1973
1. On January 1, 1970 the National Environmental Protection Act became law in the United States, and has been further strengthened by judicial interpretations. This act requires, among other things, a presentation of information to justify the effect of projects on the environment of both public and private works controlled by the permit process of the
openaire   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

The Association Between Skeletal Facial Types and Third Molars Impaction in a Saudi Arabian Subpopulation: A CBCT Study

open access: yesClinical, Cosmetic and Investigational Dentistry, 2023
Muslat A Bin Rubaia’an,1 Aymen Neyaz,1 Faisal Talic,1 Ali Alkhamis,1 Abdulmalek Alghabban,1 Ahmad Assari2 1College of Dentistry, Riyadh Elm University, Riyadh, Kingdom of Saudi Arabia; 2Oral and Maxillofacial Surgery and Diagnostic Sciences Department ...
Bin Rubaia'an MA   +5 more
doaj  

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Method of Diagnosis and Treatment of Impacted Teeth on the Upper Jaw [PDF]

open access: diamond, 2020
MA Postnikov   +3 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Patterns of Understory Diversity in Mixed Coniferous Forests of Southern California Impacted by Air Pollution [PDF]

open access: gold, 2007
Edith B. Allen   +5 more
openalex   +1 more source

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