Results 101 to 110 of about 2,558,373 (316)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Impacts of Tourboats in Marine Environments

, 2004
This review characterizes tourboat operators and their impacts based on technical knowledge and information collected from interviews with Australian operators in seven geographical regions.
Warnken, Jan, T. Byrnes, J. Warnken, Byrnes, Troy   +3 more
core   +1 more source

The economic costs of precision medicine for clinical translational research among children with high-risk cancer

npj Precision Oncology
Embedding precision medicine in paediatric oncology shows promise to have a positive impact on how children with cancer will be treated in the future.
Christopher E. L. Owens, Owen Tan, Joice Kuroiwa-Trzmielina, Rupendra N. Shrestha, Tracey O’Brien, Vanessa Tyrrell, Deborah J. Schofield   +6 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The Impact of Impact: An Invitation to Philosophise

Minerva
Abstract This position paper argues for the introduction of a philosophy of research impact, as an invitation to think deeply about the implications of the impact agenda. It delves into the transformative influence of prioritising the end-product of the research journey over the entire knowledge production process.
Rene Brauer, Ismo Björn, Glenn Burgess, Mirek Dymitrow, John Greenman, Elżbieta Grzelak-Kostulska, Pirjo Pöllänen, Terry Williams   +7 more
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

$100 a barrel of oil : impacts on the sustainability of food supply in the UK

, 2012
This document is summarised in '$100 a barrel of oil : impacts on the sustainability of food supply in the UK [executive summary]'.This study asks a simple question: what would be the impact on food of oil prices rising to $100 a barrel?
ADAS
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The impacts of climate change across the globe: a multi-sectoral assessment [PDF]

, 2014
The overall global-scale consequences of climate change are dependent on the distribution of impacts across regions, and there are multiple dimensions to these impacts.
Gottschalk, P., Lloyd-Hughes, Ben, Wheeler, T. R., Nicholls, R. J., Smith, P., Arnell, N.W., Gottschalk, J. Hinkel, R. J. Nicholls, Osborne, T. M., Lowe, Jason Anthony, Rose, G. A., N. W. Arnell, J. Hinkel, Rose, G.A., B. Lloyd-Hughes, S. Brown, Huntingford, C., Osborne, T.M., P. Gottschalk, C. Huntingford, Wheeler, T.R., Brown, S., Gosling, S.N., Zelazowski, P., P. Smith, Gosling, S. N., Gosling, Simon N., Arnell, Nigel W., T. R. Wheeler, Hinkel, J., Wheeler, Tim R., Lloyd-Hughes, B., Huntingford, Chris, Nicholls, R.J., Osborne, Tom M., Lowe, J.A., T. J. Osborn, G. A. Rose, Rose, Gillian A., J. A. Lowe, Arnell, N. W., Arnell, Nigel, Osborn, T. J., T. M. Osborne, Osborn, T.J., P. Zelazowski, Brown, Sally, Lowe, J. A., S. N. Gosling   +48 more
core   +1 more source