Results 111 to 120 of about 2,558,373 (316)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Heterogeneous Impacts in PROGRESA [PDF]
The “common effect” model in program evaluation assumes that all treated individuals have the same impact from a program. Our paper contributes to the recent literature that tests and goes beyond the common effect model by investigating impact ...
Djebbari, Habiba, Smith, Jeffrey A.
core
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Festival and event tourism impacts
, 2020 Festival and Event Tourism Impacts provides a comprehensive review and analysis of the multi-faceted impacts that festival and events have on a host community, whether positive or negative, and offers recommendations for communities for the successful ...
Yolal, M, Gursoy, D, Nunkoo, R
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Annual Report 2024: Accelerating Impacts of CGIAR Climate Research for Africa (AICCRA)
Accelerating Impacts of CGIAR Climate Research for Africa (AICCRA) is a project administered by the Alliance of Bioversity International and the International Centre for Tropical Agriculture (CIAT).
Accelerating Impacts of CGIAR Climate Research for Africa
core
The perceived social impacts of the 2006 World Cup on Munich residents
, 2006 All major sporting events result in a variety of impacts upon the host community. To date, the majority of existing studies have focused upon the wider economic impacts, with few empirical studies of the social impacts upon local residents.
Wilkes, Keith +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
AtmosphereMeteorological reanalyses are one of the means to assess the solar irradiance reaching the ground. This paper deals with estimates of the hourly means of irradiance in clear-sky conditions provided by the ERA5, JRA-3Q, and MERRA-2 reanalyses.
Yves-Marie Saint-Drenan, Lucien Wald
doaj +1 more source