Results 161 to 170 of about 364,049 (308)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Association of impaired fasting glucose with cardiometabolic multimorbidity: The Kailuan study. [PDF]

J Diabetes Investig
Guo Z, Wu S, Zheng M, Xia P, Li Q, He Q, Song Z.   +6 more
europepmc   +1 more source

A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. [PDF]

Diabetes, 2023
Nogal A, Tettamanzi F, Dong Q, Louca P, Visconti A, Christiansen C, Breuninger T, Linseisen J, Grallert H, Wawro N, Asnicar F, Wong K, Baleanu AF, Michelotti GA, Segata N, Falchi M, Peters A, Franks PW, Bagnardi V, Spector TD, Bell JT, Gieger C, Valdes AM, Menni C.   +23 more
europepmc   +1 more source

A Higher Serum Anion Gap is Associated with the Risk of Progressing to Impaired Fasting Glucose and Diabetes

, 2021
Yingchao Zhang, Fengran Xiong, Ruxuan Zhao, Tingting Shi, Jin-Kui Yang, Jing Lu   +5 more
openalex   +1 more source

One-Hour Postload Hyperglycemia Is a Stronger Predictor of Type 2 Diabetes Than Impaired Fasting Glucose.

Journal of Clinical Endocrinology and Metabolism, 2015
T. V. Fiorentino, M. A. Marini, F. Andreozzi, F. Arturi, E. Succurro, M. Perticone, A. Sciacqua, M. Hribal, F. Perticone, G. Sesti   +9 more
semanticscholar   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Association between the aspartate aminotransferase-to-alanine aminotransferase ratio and the reversion to normoglycemia in people with impaired fasting glucose: a 5-year retrospective cohort study. [PDF]

Front Endocrinol (Lausanne)
Zhang K, Chen L, Deng Z, Rong R, Xu L, Xu L, Zeng S, Hu H.   +7 more
europepmc   +1 more source

Prevalence of type 2 diabetes and impaired fasting glucose in patients affected by rheumatoid arthritis

, 2017
Piero Ruscitti, Francesco Ursini, Paola Cipriani, Francesco Ciccia, Vasiliki Liakouli, Francesco Carubbi, Giuliana Guggino, Onorina Berardicurti, Rosa Daniela Grembiale, G Triolo, Giovambattista De Sarro, Roberto Giacomelli   +11 more
openalex   +1 more source

Cardiometabolic Risk in Impaired Fasting Glucose and Impaired Glucose Tolerance [PDF]

, 2007
James S. Pankow, David Kwan, Bruce Bartholow Duncan, María Inês Schmidt, David Couper, Sherita Hill Golden, Christie M. Ballantyne   +6 more
openalex   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

Advanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu, Yajie Zhang, Yushi Tang, Hongli Hu, Ying Zhang, Junwen Xue, Hao Wang, Yecheng Wang, Chunfeng Liu, Jia Jia, Jian Cheng, Yongjun Cao   +11 more
wiley   +1 more source