Results 71 to 80 of about 1,760,363 (317)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Attitude of first-year students of physiotherapy towards their field of study and future career in Babol University of Medical Sciences

آموزش پزشکی, 2018
BACKGROUND AND OBJECTIVE: Attitude Students towards the field of study and the future career should always be considered by health authorities of education and welfare system in each country. Positive attitudes can lead to increase students' satisfaction
Arsalan Ghourbanpour, Ghadam Ali Talebi, Mohammad Taghipour   +2 more
doaj  

Uma análise do teste de impairment nas publicações científicas entre os anos de 2000 e 2007 [PDF]

, 2007
TCC (Graduação) - Universidade Federal de Santa Catarina. Centro Socioeconômico. Curso de Ciências ContábeisEste estudo faz uma análise das publicações científicas sobre o teste de impairment em revistas acadêmicas e congressos da área contábil em língua
Zandonai, Fabiana
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Visuoconstructional Impairment in Subtypes of Mild Cognitive Impairment [PDF]

Applied Neuropsychology: Adult, 2015
Clock Drawing Test performance was examined alongside other neuropsychological tests in mild cognitive impairment (MCI). We tested the hypothesis that clock-drawing errors are related to executive impairment. The current research examined 86 patients with MCI for whom, in prior research, cluster analysis was used to sort patients into dysexecutive ...
Ahmed, Samrah, Brennan, Laura, Eppig, Joel, Price, Catherine C, Lamar, Melissa, Delano-Wood, Lisa, Bangen, Katherine J, Edmonds, Emily C, Clark, Lindsey, Nation, Daniel A, Jak, Amy, Au, Rhoda, Swenson, Rodney, Bondi, Mark W, Libon, David J   +14 more
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An impairment in sniffing contributes to the olfactory impairment in Parkinson's disease [PDF]

Proceedings of the National Academy of Sciences, 2001
Although the presence of an olfactory impairment in Parkinson's disease (PD) has been recognized for 25 years, its cause remains unclear. Here we suggest a contributing factor to this impairment, namely, that PD impairs active sniffing of odorants. We tested 10 men and 10 women with clinically typical PD, and 20 age- and gender-matched
Stappen, Iris, Sobel, N., Thomason, Moriah, Tanner, Caroline M., Gabrieli, J.D.E., Bower, James M, Sullivan, Edith V., Tetrud, James W.   +7 more
openaire   +4 more sources

Perceived Stigmatization of Children with Speech-Language Impairment and Their Parents [PDF]

, 2008
Objective: Developmental disorders in childhood are generally assumed to have stigmatizing effects. The goal of the present study was to assess whether parents of children with speech-language impairment perceive stigmatization of their child or ...
Macharey, Georg, Suchodoletz, Waldemar von   +1 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source