Results 81 to 90 of about 43,346 (264)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Line impedance anomaly detection based on OPTICS [PDF]

AIP Advances
The accurate identification of distribution substation area topology and precise diagnosis of potential hazards in low-voltage distribution networks are essential for advancing intelligent power distribution and enhancing grid security.
Chen Gao, Yaping Wang, Xinwei Liang
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

A noninvasive ultrasonic method for vascular input impedance determination applied in diagnosis of the carotid arteries

Archives of Acoustics, 2015
In this study, a new method is presented for diagnosis of the extracranial carotid arteries, based on analysis of the vascular input impedance noninvasively determined in human common carotid arteries.
Tadeusz POWAŁOWSKI
doaj  

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bioelectrical Impedance Spectroscopy (BIS) For Ratiometric Identification

Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics
This research explores the potential use of Electrical Impedance Spectroscopy (EIS) and ratiometric methods to improve security and reproducibility in bioelectrical impedance-based biometric authentication systems. Traditional biometric technologies such as fingerprints are susceptible to forgery and less effective in handling external variations ...
Elmira Rofida Alhaq, Umaimah Mitssalia Umi Salwa, Khusnul Ain, Imam Sapuan   +3 more
openaire   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

An Identification Method of Dominant Instability Factors in the New Power System Using the Apparent Power Phasor Trajectory

Mathematics
Recently, a new stability classification including the frequency, voltage, power angle, and impedance angle stability has been proposed. However, instability coupling among the voltage, power angle, and impedance angle may occur.
Haoran Zhang, Xiaohua Zhang, Haoyuan Xu, Shuai Li, Chuang Huang, Xuelin Zhang   +5 more
doaj   +1 more source