Results 91 to 100 of about 131,295 (296)

Theoretical research on the application of impedance calculation in the design of high-intensity low-frequency acoustic generator

open access: yesJournal of Low Frequency Noise, Vibration and Active Control
The impedance matching is essential in producing high-intensity acoustic waves. This paper studies the impedance calculation methods of modulators and double-chamber Helmholtz resonators based on fluid mechanics, aeroacoustics, and electro-acoustic ...
Baoguo Zhang   +6 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Impedance matching in photonic crystal microcavities for Second Harmonic Generation

open access: yes, 2005
By numerically integrating the three-dimensional Maxwell equations in the time domain with reference to a dispersive quadratically nonlinear material, we study second harmonic generation in planar photonic crystal microresonators.
Andrea Di Falco   +21 more
core   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Design and Performance Evaluation of a μ-Synthesis-Based Robust Impedance Controller for Robotic Joints

open access: yesActuators
This paper proposes a robust impedance controller to address the performance limitations of mechanical impedance rendering in robotic joints, enabling stable interaction with passive environments.
Nianfeng Shao   +3 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Three-Dimensional Package Design for Electro-Absorption Modulation Laser Array

open access: yesIEEE Photonics Journal, 2016
We report a new 3-D package design technique in this paper. Based on this technique, a 3-D RF impedance matching circuit used in the packaging of electroabsorption modulation laser (EML) array is achieved, which has the characteristics of low electrical ...
Zhike Zhang   +7 more
doaj   +1 more source

Modelling of a novel high-impedance matching layer for high frequency (>30 MHz) ultrasonic transducers

open access: yes, 2013
This work describes a new approach to impedance matching for ultrasonic transducers. A single matching layer with high acoustic impedance of 16 MRayls is demonstrated to show a bandwidth of around 70%, compared with conventional single matching layer ...
Harris, N.R., Qian, Yi Chen
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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