Results 91 to 100 of about 28,708 (260)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Simulation-Based Approach to the Matching of a Dielectric-Filled Circular Waveguide Aperture

open access: yesSensors
The circular waveguide aperture or open-end radiator, one of the canonical antenna elements, can be filled with a dielectric material for miniaturization.
Songyuan Xu   +4 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

open access: yesFEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Design and operation of a load-tolerant ICRH system in Experimental Advanced Superconducting Tokamak

open access: yesNuclear Fusion
Ion Cyclotron Resonance Heating (ICRH) has been a dependable tool for sturdy plasma heating with high RF power of several megawatts. However, a sudden increase in the reflected power during ICRH heating experiments is a problem that should be solved for ...
L.N. Liu   +9 more
doaj   +1 more source

A Wide-Bandwidth PVT-Reconfigurable CMOS Power Amplifier with an Integrated Tunable-Output Impedance Matching Network. [PDF]

open access: yesMicromachines (Basel), 2023
Mariappan S   +6 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

Strong and wide microwave absorption of multilayered metastructure enhanced by impedance matching mechanism

open access: yesResults in Physics
The present study proposes a strong and wide microwave absorption of multilayered metastructure (SWMAMM) capable of achieving an ultra-wideband absorption of −20 dB and 60° oblique incidence. SWMAMM primarily consists of metasurface-Ⅰ (MS-Ⅰ), metasurface-
Zheyipei Ma, Yanqiong Liu, Chao Jiang
doaj   +1 more source

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