Results 51 to 60 of about 28,834 (268)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Impedance Modeling Based Method for Sub/Supsynchronous Oscillation Analysis of D-PMSG Wind Farm

open access: yesApplied Sciences, 2019
Subsynchronous oscillation (SSO) is a critical issue for the direct-drive permanent magnet synchronous generator (D-PMSG) based wind farm integrated to a weak onshore AC grid.
Saijun Yuan   +4 more
doaj   +1 more source

Impedance Modeling and Stability Analysis of the IMAF-PLL-Based NPC Three-Level LCL Grid-Connected Inverter

open access: yesIEEE Access, 2020
The phase-locked loop of grid-connected inverters affects their output impedance characteristics and stability. Based on the NPC, three-level LCL grid-connected inverter, this article first analyzes the frequency characteristics of the improved moving ...
Wei Luo, Dafang Wei, Jianguo Jiang
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Time domain impedance modelling and applications

open access: yesProcedia Engineering, 2010
AbstractToday, there is a high, often not fully evolved potential of noise attenuation by passive acoustic treatments. Current numerical methods are able to help developing optimal treatments. Thus, the simulation of acoustic lining in aeroengines is one of the core objectives for the development of modern CAA solvers.
Richter, Ch.   +5 more
openaire   +2 more sources

Model for the Evaluation of an Angular Slot’s Coupling Impedance [PDF]

open access: yesSymmetry, 2019
In high energy particle accelerators, a careful modeling of the electromagnetic interaction between the particle beam and the structure is essential to ensure the performance of the experiments. Particular interest arises in the presence of angular discontinuities of the structure, due to the asymmetrical behavior.
Assante, Dario, Verolino, Luigi
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

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