Results 101 to 110 of about 222,901 (291)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Circuital and Numerical Models for Calculation of Shielding Effectiveness of Enclosure with Apertures and Monitoring Dipole Antenna Inside [PDF]

, 2013
In this paper, circuital and numerical models of metal In this paper, circuital and numerical models of metal enclosure with apertures are considered for the purpose of accurate shielding effectiveness calculation.
B. Milovanović, N. Doncov, T. Cvetković, V. Milutinović   +3 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A 0.8 V T Network-Based 2.6 GHz Downconverter RFIC [PDF]

, 2012
A 2.6 GHz downconverter RFIC is designed and implemented using a 0.18 μm CMOS standard process. An important goal of the design is to achieve the high linearity that is required in WiMAX systems with a low supply voltage.
Chuang, C.-J., Kuo, Y., Liou, C.-K., Wu, J.-M.   +3 more
core   +1 more source

Dependence of microwave absorption properties on ferrite volume fraction in MnZn ferrite/rubber radar absorbing materials

, 2011
We report the analysis of measurements of the complex magnetic permeability ($\mu_r$) and dielectric permittivity ($\epsilon_r$) spectra of a rubber radar absorbing material (RAM) with various MnZn ferrite volume fractions.
Dantas, Christine C., Gama, Adriana M., Rezende, Mirabel C.   +2 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

A Dual-Path Neural Network for High-Impedance Fault Detection

Mathematics
High-impedance fault detection poses significant challenges for distribution network maintenance and operation. We propose a dual-path neural network for high-impedance fault detection.
Keqing Ning, Lin Ye, Wei Song, Wei Guo, Guanyuan Li, Xiang Yin, Mingze Zhang   +6 more
doaj   +1 more source

Research on impedance matching method for magnetic resonant coupling wireless power transmission system

Gong-kuang zidonghua, 2019
In view of the problem that the input impedance does not match the RF internal resistance and the output power decreases due to the change of transmission distance or load in magnetic resonant coupling wireless power transmission system, an impedance ...
YUAN Shiqiang, CUI Yulong, WANG Jingqin, FAN Haoliang, FAN Yachao   +4 more
doaj   +1 more source