Results 71 to 80 of about 206,183 (273)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A Comparison of Online Electrochemical Spectroscopy Impedance Estimation of Batteries

open access: yesIEEE Access, 2018
This paper compares the methods of undertaking on-line electrochemical impedance spectroscopy that have been published in the literature. This paper describes the different published methodologies and sorts these into categories.
Mina Abedi Varnosfaderani   +1 more
doaj   +1 more source

Effect of cerium concentration on corrosion resistance and polymerization of hybrid sol–gel coating on martensitic stainless steel [PDF]

open access: yes, 2012
Stainless steels are increasingly used in the aeronautics field for the manufacture of structural parts. One of them, the X13VD martensitic stainless steel (X12CrNiMoV12-3), known for its good mechanical properties, has a poor corrosion resistance in ...
Ansart, Florence   +3 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Electrochemical Evaluation and Phase-related Impedance Studies on Silicon–Few Layer Graphene (FLG) Composite Electrode Systems

open access: yesScientific Reports, 2018
Silicon-Few Layer Graphene (Si-FLG) composite electrodes are investigated using a scalable electrode manufacturing method. A comprehensive study on the electrochemical performance and the impedance response is measured using electrochemical impedance ...
Qianye Huang   +4 more
doaj   +1 more source

Zero-bias anomalies on Sr$_{0.88}$La$_{0.12}$CuO$_2$ thin films

open access: yes, 2012
High-impedance contacts made on the surface of Sr$_{0.88}$La$_{0.12}$CuO$_2$ superconducting thin films systematically display a zero-bias anomaly. We consider two-level systems (TLS) as the origin of this anomaly.
Akimenko   +36 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

Bioimpedance spectroscopy of breast phantoms

open access: yesJournal of Electrical Bioimpedance
This article is devoted to the study of the possibility of detecting breast tumors, which can be used for early diagnostics of breast cancer, by the dielectric impedance spectroscopy method.
Kuzmin Andrey, Baranov Viktor
doaj   +1 more source

Four-Wire Impedance Spectroscopy on Planar Zeolite/Chromium Oxide Based Hydrocarbon Gas Sensors

open access: yesSensors, 2007
Impedometric zeolite hydrocarbon sensors with a chromium oxide intermediatelayer show a very promising behavior with respect to sensitivity and selectivity. Theunderlying physico-chemical mechanism is under investigation at the moment.
Ralf Moos   +3 more
doaj   +1 more source

The intrinsic electrical equivalent circuit of a laser diode [PDF]

open access: yes, 1981
The basic electrical equivalent circuit of a laser diode is derived. The effects of spontaneous emission and self-pulsations are included. It is found that self-pulsations are represented by a negative resistance in the model.
Harder, C.   +4 more
core   +1 more source

Home - About - Disclaimer - Privacy