Results 131 to 140 of about 426,366 (315)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Implante imediato em área estética: uma revisão de literatura [PDF]

, 2015
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.Ao longo da história, a Implantodontia adaptou-se às novas necessidades exigidas tanto pelos pacientes quanto por evoluções das técnicas e teorias.
Vieira, Fernanda Espíndola
core  

Evaluation of Impression Accuracy for Implant at Various Angulations

, 2010
Purpose: The purpose of this study was to compare 2 splinted impression transfer techniques for implant-supported prostheses.Materials: A metal matrix (control) with 4 implants was used.
Britto, Rebeca Cavalcante, Assunção, Wirley Goncalves [UNESP], Ricardo Barao, Valentim Adelino [UNESP], Ricardo Barao, Valentim Adelino, Santos, Paulo Henrique dos, Santos, Paulo Henrique dos [UNESP], Delben, Juliana Aparecida, Assunção, Wirley Goncalves, Delben, Juliana Aparecida [UNESP]   +8 more
core   +1 more source

Intramedullary nail design for Thais with novel multi-femur shape optimization approach

Scientific Reports
Femoral fractures, often resulting from high-energy accidents, are commonly treated with intramedullary nails. Most currently used intramedullary nails are designed based on the anatomical characteristics of the Caucasian population, which are unsuitable
Duangkamon Sayabut, Chanyaphan Virulsri, Pairat Tangpornprasert   +2 more
doaj   +1 more source

Primary Stability of Implants Inserted Using Different Osseodensification Systems in Low-Density Bone: An In Vitro Study

Dentistry Journal
Background/Objectives: It remains unclear which drilling strategy is most effective for maximizing mechanical stability in low-density bone and whether high insertion torque is determinative.
André Luís Onodera, Alexandre Wanderley Alécio, Gustavo Batista Grolli Klein, Sheila Cortelli, Rogério de Lima Romeiro   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The saga of Poly Implant Prosthese breast implants

BMJ, 2012
Urgent review of the regulation and postmarketing evidence requirements is needed Complete and utter confusion now reigns over Poly Implant Prosthese (PIP) breast implants and what to do, particularly with regard to the evidence needed for their regulation, effectiveness, and, more importantly, safety.
openaire   +4 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Association of Interleukin 4 Gene Polymorphisms With Dental Implant Loss

, 2014
Purpose: The purpose of this study was to investigate the association between interleukin 4 (IL4) polymorphisms/haplotypes and dental implant loss.Materials and Methods: Two hundred and seventy eight (n = 278) unrelated patients were divided into 2 ...
Scarel-Caminaga, Raquel M. [UNESP], Claudia C. K. Alvim-Pereira, Trevilatto, Paula C., Paula C. Trevilatto, Alvim-Pereira, Fabiano, Fabiano Alvim-Pereira, Alvim-Pereira, Claudia C. K., Scarel-Caminaga, Raquel M., Pigossi, Suzane C. [UNESP], Suzane C. Pigossi, Raquel M. Scarel-Caminaga, Pigossi, Suzane C.   +11 more
core   +1 more source

Roles of VWA1 and Rac2 in compensatory and decompensatory responses via FGF9/FGFR3 and p38 MAPK signaling pathways in condylar chondrocytes under distinct mechanical stress

Arthritis Research & Therapy
Background/purpose Few studies paid attention to compensatory and decompensatory responses of condylar cartilage under different mechanical conditions and the underlying mechanism.
Yuqi Liu, Fangwen Jia, Kangya Li, Chao Liang, Yanxi Li, Wei Geng   +5 more
doaj   +1 more source