Results 111 to 120 of about 483,999 (304)

AI-Driven CBCT Analysis for Surgical Decision-Making and Mucosal Damage Prediction in Sinus Lift Surgery for patients with low RBH

International Dental Journal
Background: Decision-making for maxillary sinus floor elevation (MSFE) surgery in patients with low residual bone height (
Yinxin Deng, Yilin He, Changying Liu, Zhenhua Gao, Shujia Yu, Shiyu Cao, Chenrui Li, Qian Zhu, Pan Ma   +8 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Dentoalveolar Complex Autotransplantation in Esthetic Zone Rehabilitation: A Case Report

Case Reports in Dentistry
Tooth autotransplantation is a biologically favorable option for the replacement of missing teeth and has demonstrated predictable outcomes with both immature and mature donor teeth.
Gurgen V. Khachatrian, Jaime L. Lozada, Robert A. Handysides, Ekaterina A. Zernitckaia   +3 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Influence of parallel pins on the angle deviation for placement of dental implants: an in vitro study

BMC Oral Health
The aim of the present study was to analyze and compare the angle deviation of two, four and six adjacent dental implants placed with and without straight parallel pins. Materials and Methods: Two hundred and forty (240) dental implants were selected and
Héctor González Menéndez, Juan Lorrio Castro, Paulina Rodríguez Torres, Susana de la Vega Buró, Álvaro Zubizarreta-Macho, Elena Riad Deglow, Ana Belén Lobo Galindo, Sofía Hernández Montero   +7 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Timing of implant-removal in late acute periprosthetic joint infection: A multicenter observational study

, 2019
: Objectives: We evaluated the treatment outcome in late acute (LA) periprosthetic joint infections (PJI) treated with debridement and implant retention (DAIR) versus implant removal.
Tufan, Zeliha Kocak, Cobo Reinoso, Javier, Gomez-Junyent, Joan, Chaves, Fernando, Blanco Garcia, Antonio, Demirturk, Aybegum, Shohat, Noam, Coll, Pere, Arvieux, Cedric, Common, Harold, Noth, Ulrich, Mur, Isabel, Ferrari, Matteo Carlo, Gougeon, Anne, Crusi, Xavier, Digumber, Marc, Tarabichi, Majd, Ribeiro, Taiana, Sanchez, Marisa, Scarborough, Matthew, Trebse, Rihard, Morata, Laura, Diaz-Brito, Vicens, Benito, Natividad, Petersdorf, Sabine, Salles, Mauro Jose, Fernandez-Sampedro, Marta, Polesello, Giancarlo, Esteban, Jaime, Soriano, Alex, Moreno, Encarna, Garcia-Canete, Joaquin, Smolders, David, Sebillotte, Marine, Vaznaisiene, Danguole, Tornero, Eduard, Bori, Guillem, Pfang, Bernadette Genevieve, Aboltins, Craig, Dolores Del Toro, Maria, Huotari, Kaisa, Kendrick, Benjamin, Mancheno, Mikel, Tattevin, Pierre, Escudero Sanchez, Rosa, Honda, Emerson, Dapas, Juan, Inthavong, Phongsakone, Taylor, Adrian, Kramer, Tobias Siegfried, Yusuf, Erlangga, Senneville, Eric, Lomas, Jose, Rivero, Cynthia, Wouthuyzen-Bakker, Marjan, Parvizi, Javad, Lowik, Claudia, Benavent Palomares, Eva, Barbero Allende, Jose Maria, Lora-Tamayo, Jaime, Ploegmakers, Joris, Lozano, Luis, Murillo, Oscar, Vila, Andrea, Jutte, Paul, Meheut, Anne   +65 more
core  

Targeted long-read nanopore sequencing as a complementary approach for detecting STRC variants and distinguishing the STRCP1 pseudogene

Scientific Reports
The stereocilin (STRC) gene is a significant contributor to mild-to-moderate sensorineural hearing loss (SNHL), particularly in cases of biallelic STRC deletions and copy number alterations.
Hideaki Moteki, Shin-ya Nishio, Shin-ichi Usami   +2 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source