Results 81 to 90 of about 1,869,696 (253)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Acoustic models of consonant recognition in cochlear implant users [PDF]

, 2007
Normal-hearing adults have no difficulty in recognising consonants accurately, even in moderately adverse listening conditions. By contrast, users of multichannel cochlear implants have difficulty with the accurate perception of consonants, even in good ...
Verschuur, Carl
core   +1 more source

The Risk Factors in Early Failure of Dental Implants: a Retrospective Study

Journal of Dentistry, 2017
Statement of the Problem: Despite the low failure rate of dental implants, recognition of the risk factors can enhance the predictability of failure. Purpose: The aim of this study was to evaluate the risk factors for early implant failure.
Hassan Mohajerani , Roozbeh Roozbayani , Shahram Taherian , Reza Tabrizi   +3 more
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Study of the Associated Risk Factors for Early Failure and the Effect of Photofunctionalisation in Full-Arch Immediate Loading Treatment Based on the All-on-Four Concept

Bioengineering
Early implant failure occurring within 1 year after implantation has been attributed to various factors. Particularly, early failure can lead to challenges in maintaining a full-arch prosthetic device, necessitating prompt intervention, including ...
Takashi Uesugi, Yoshiaki Shimoo, Motohiro Munakata, Yu Kataoka, Daisuke Sato, Kikue Yamaguchi, Minoru Sanda, Michiya Fujimaki, Kazuhisa Nakayama, Tae Watanabe, Paulo Malo   +10 more
doaj   +1 more source

Clinical Management of Implant Prostheses in Patients with Bruxism

International Journal of Biomaterials, 2012
There is general agreement that excessive stress to the bone-implant interface may result in implant overload and failure. Early failure of the implant due to excessive loading occurs shortly after uncovering the implant.
Osamu Komiyama, Frank Lobbezoo, Antoon De Laat, Takashi Iida, Tsuyoshi Kitagawa, Hiroshi Murakami, Takao Kato, Misao Kawara   +7 more
doaj   +1 more source

An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure

, 2016
Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose: The objective of this case-control study was to explore the impact
De Paepe, Anne,, Koningsveld, Vincent, Cosyn, Jan,, Paul J. Coucke, Cosyn, JanGE368020001712020000-0001-5042-2875F8D9B8EE-F0ED-11E1-A9DE-61C894A0A6B4, Cosyn, Jan, De Paepe, Anne, Hugo De Bruyn, Jan Cosyn, De Bruyn, Hugo,, Véronique Christiaens, Christiaens, VéroniqueGE36UZGent0000604968768020005940590000-0002-0938-888716A2404E-F0EE-11E1-A9DE-61C894A0A6B4, De Paepe, AnneGE31UZGent8010004612130000-0002-4134-5940F403A000-F0ED-11E1-A9DE-61C894A0A6B4, De Bruyn, HugoGE36UZGent0000705496158010018893350000-0003-0200-9546F73EAFBC-F0ED-11E1-A9DE-61C894A0A6B4, Vincent Koningsveld, Christiaens, Véronique,, Coucke, PaulGE31UZGent0001712314708010016360240000-0001-7119-586XF6730D80-F0ED-11E1-A9DE-61C894A0A6B4, Christiaens, Véronique, Koningsveld, Vincent,, Coucke, Paul, Coucke, Paul J,, De Bruyn, Hugo, De Coster, Peter, Koningsveld, Vincent00006070583291902352098517111D3E-F0EE-11E1-A9DE-61C894A0A6B4, De Coster, Peter,, Peter De Coster, De Coster, PeterGE360019801975078010013777600000-0002-0674-7733F5D3E7D2-F0ED-11E1-A9DE-61C894A0A6B4, Anne De Paepe   +27 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Prevalência das doenças periimplantares mucosite e periimplantite . Análise de fatores de risco locais e sistêmicos. Estudo retrospectivo de 1 a 9 anos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2012Objetivo : Determinar a prevalência de doenças periimplantares; mucosite e periimplantite, nos pacientes ...
Buttendorf, André Ricardo
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source