Results 101 to 110 of about 1,620,931 (303)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Clinical consequences early implant failures of IL-1 genotype on early implant failures in patients under periodontal maintenance

, 2005
Background: Implant failure and biologic complications such as periimplantitis are not completely avoidable. Are there any genetic and microbiologic parameters that Could be used to identify patients at risk for implant failure, preferably prior to ...
De Bruyn, HugoGE36UZGent0000705496158010018893350000-0003-0200-9546F73EAFBC-F0ED-11E1-A9DE-61C894A0A6B4, De Bruyn, Hugo, Hamberg, Kristina,, Bratthall, Gunilla, de Bruyn, Hugo,, Bratthall, Gunilla,, Jansson, Henrik, Hamberg, Kristina, Jansson, Henrik,   +8 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

An exploratory case-control study on the impact of IL-1 gene polymorphisms on early implant failure

, 2016
Background: The association between IL-1 gene polymorphisms and peri-implantitis has been well documented. However, data on the association with early implant failure are scarce. Purpose: The objective of this case-control study was to explore the impact
De Paepe, Anne,, Koningsveld, Vincent, Cosyn, Jan,, Paul J. Coucke, Cosyn, JanGE368020001712020000-0001-5042-2875F8D9B8EE-F0ED-11E1-A9DE-61C894A0A6B4, Cosyn, Jan, De Paepe, Anne, Hugo De Bruyn, Jan Cosyn, De Bruyn, Hugo,, Véronique Christiaens, Christiaens, VéroniqueGE36UZGent0000604968768020005940590000-0002-0938-888716A2404E-F0EE-11E1-A9DE-61C894A0A6B4, De Paepe, AnneGE31UZGent8010004612130000-0002-4134-5940F403A000-F0ED-11E1-A9DE-61C894A0A6B4, De Bruyn, HugoGE36UZGent0000705496158010018893350000-0003-0200-9546F73EAFBC-F0ED-11E1-A9DE-61C894A0A6B4, Vincent Koningsveld, Christiaens, Véronique,, Coucke, PaulGE31UZGent0001712314708010016360240000-0001-7119-586XF6730D80-F0ED-11E1-A9DE-61C894A0A6B4, Christiaens, Véronique, Koningsveld, Vincent,, Coucke, Paul, Coucke, Paul J,, De Bruyn, Hugo, De Coster, Peter, Koningsveld, Vincent00006070583291902352098517111D3E-F0EE-11E1-A9DE-61C894A0A6B4, De Coster, Peter,, Peter De Coster, De Coster, PeterGE360019801975078010013777600000-0002-0674-7733F5D3E7D2-F0ED-11E1-A9DE-61C894A0A6B4, Anne De Paepe   +27 more
core   +1 more source

Assessing the Impact of Dental Implant Length on Early Failure Rates: A Retrospective Analysis

Journal of Pharmacy and Bioallied Sciences
Introduction: The selection criteria of implant is very critical. Implant length determines the mechanics of osseointegration. Objective: To investigate the influence of dental implant length on early failure rates, osseointegration success, peri-implant
Bhuvaneshwari Karthikeyan, K Hanumantha Kumar, K. Sadananda, Inderjit Murugendrappa Gowdar, Shital J. Sonune, Doaa Abdelaziz A. Helal   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Prevalência das doenças periimplantares mucosite e periimplantite . Análise de fatores de risco locais e sistêmicos. Estudo retrospectivo de 1 a 9 anos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2012Objetivo : Determinar a prevalência de doenças periimplantares; mucosite e periimplantite, nos pacientes ...
Buttendorf, André Ricardo
core  

Influence of Prognostic Risk Indicators on Osseointegrated Dental Implant Failure: A Matched Case-Control Analysis

, 2012
Dental implant treatment is an important therapeutic modality with documented long-term success for replacement of missing teeth. However, dental implants can be susceptible to disease conditions or healing complications that may lead to implant loss ...
Rami Alissa, Richard J. Oliver
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source