Results 81 to 90 of about 2,414,398 (303)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

The Risk Factors in Early Failure of Dental Implants: a Retrospective Study

Journal of Dentistry, 2017
Statement of the Problem: Despite the low failure rate of dental implants, recognition of the risk factors can enhance the predictability of failure. Purpose: The aim of this study was to evaluate the risk factors for early implant failure.
Hassan Mohajerani , Roozbeh Roozbayani , Shahram Taherian , Reza Tabrizi   +3 more
doaj  

Effect of plaque accumulation and occlusal overload on peri-implant bone loss

Journal of Biological Research, 2017
This paper presents a case report where the influence of plaque accumulation and overload on a dental implant was observed. The patient presented crown loss on one implant affected by peri-implant bone resorption and gingival inflammation associated with
Elena Dellepiane, Maria Menini, Paolo Canepa, Paolo Pera   +3 more
doaj   +1 more source

Molecular aspects of implantation failure

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2012
Despite expanding global experience with advanced reproductive technologies, the majority of IVF attempts do not result in a successful pregnancy, foremost as a result of implantation failure. The process of embryo implantation, a remarkably dynamic and precisely controlled molecular and cellular event, appears inefficient in humans and is poorly ...
Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, J.J., Macklon, N.S.   +4 more
openaire   +3 more sources

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Influence of Diabetes on Implant Failure and Peri-Implant Diseases: A Retrospective Study

Dentistry Journal, 2020
Diabetes is an important modifying factor of periodontitis, but its association with peri-implant diseases has not been fully explored and the existing literature reports controversial results.
Alice Alberti, Paolo Morandi, Beatrice Zotti, Francesco Tironi, Luca Francetti, Silvio Taschieri, Stefano Corbella   +6 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Dentists’ Perspectives on Defining Failure in Implant-Prosthodontic Therapy: A Cross-Sectional Study

Applied Sciences
Aim: to investigate the criteria to define implant–prosthodontic therapy failure for dentists in Croatia. Methods: We conducted a cross-sectional study using an online questionnaire among dentists in Croatia.
Mare Kovic, Ajka Pribisalic, Josko Viskic, Eva Bilandzic, Anamarija Tokic, Marija Ana Perko, Tina Poklepovic Pericic   +6 more
doaj   +1 more source