Results 111 to 120 of about 2,414,398 (303)

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

FEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt, Annika Winbo, Jenny Malmström   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Implant failure in lower limb long bone diaphyseal fractures at a Tertiary Hospital in Ile- Ife, Nigeria

Nigerian Postgraduate Medical Journal, 2014
Aims and Objectives: This included determining aetiology of failure and comparing the failure rate in implant fixations using solid intramedullary nail and DCP.
O Esan, I C Ikem, E A Orimolade, O T Esan   +3 more
doaj  

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

A Study of the Associated Risk Factors for Early Failure and the Effect of Photofunctionalisation in Full-Arch Immediate Loading Treatment Based on the All-on-Four Concept

Bioengineering
Early implant failure occurring within 1 year after implantation has been attributed to various factors. Particularly, early failure can lead to challenges in maintaining a full-arch prosthetic device, necessitating prompt intervention, including ...
Takashi Uesugi, Yoshiaki Shimoo, Motohiro Munakata, Yu Kataoka, Daisuke Sato, Kikue Yamaguchi, Minoru Sanda, Michiya Fujimaki, Kazuhisa Nakayama, Tae Watanabe, Paulo Malo   +10 more
doaj   +1 more source

A Retrospective Evaluation of Treatments with Implant-Supported Maxillary Overdentures

, 2005
Background: Considerably lower success rates have been presented for implant-supported overdentures in the maxilla compared with the mandible. Purpose: The aim of the study was to report the outcome of implant-supported maxillary overdentures from one ...
Widbom, Christin,, Kronström, Mats,, Söderfeldt, Björn,   +2 more
core   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Failure Modes of Screw Fixation in Slipped Capital Femoral Epiphysis: A Proposed Life-Cycle Classification

Journal of the Pediatric Orthopaedic Society of North America
: Screw fixation is the standard surgical treatment for slipped capital femoral epiphysis. Screw-related adverse events, including implant breakage, joint penetration, fixation failure, growth-mediated construct change, removal failure, and postremoval ...
Graydon Dietrich, BS, Zayne Browning, BS, Jerard Tambunan, BSN, Ryan Dieter, BS, Kurt Soloniuk, BS, Dewayne Weaver, MD   +5 more
doaj   +1 more source

The Oral Microbiome of Peri-Implant Health and Disease: A Narrative Review

Peri-implantitis disease has increased significantly over the last years, resulting in increased failure of implants. Many factors may play a role in implant complications and failure, including ones related to the oral microbiota. This literature review
Mansour Mohamadzadeh, Peter Loomer, Yvonne de Paiva Buischi, Natalia de Campos Kajimoto   +3 more
core   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang, Linxi Cao, Xiaodong Chen, Siqi Tong, Qinghui Zhu, Jun Yang, Song Lin, Yong Cui   +7 more
wiley   +1 more source