Results 71 to 80 of about 89,381 (262)

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Mandibular implant stability in oral cancer patients: a systematic review

Journal of Oral Medicine and Oral Surgery
Introduction: Dental implants have been increasingly used in cancer patients for dental rehabilitation of the previously irradiated mandible and in mandibular reconstruction via fibula grafts but there is still debate surrounding the osseointegration ...
Brasme David, Cloitre Alexandra, Lesclous Philippe, Chaux Anne-Gaelle   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Does intraoperative bone density testing correlate with parameters of primary implant stability? A pilot study in minipigs

Clinical and Experimental Dental Research, 2019
Objectives Bone density, surgical protocol, and implant design are the major determinants of primary stability. The goal of this animal trial was to investigate potential correlations of intraoperative bone density testing with clinical and histologic ...
Tanja Grobecker‐Karl, Victor Palarie, Sonja Schneider, Matthias Karl   +3 more
doaj   +1 more source

The rate and stability of mandibular block bone graft in recent 5 years

Maxillofacial Plastic and Reconstructive Surgery, 2017
Background The purposes of the present study were to compare implant stabilities of mandibular block bone graft and bovine bone graft and to evaluate influencing factors for implant stability in mandibular block bone (MBB) graft.
Jong-Cheol Park, Yun-Ho Kim, Hong-Seok Choi, Jong-Shik Oh, Sang-Hun Shin, Yong-Deok Kim   +5 more
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

A comparative clinical study of two different attachment systems and implant stability in implant-supported mandibular overdentures

Dental Journal
Background: Implant stability is crucial for the long-term durability of implant-supported removable dentures. Understanding the clinical impact of attachment systems such as Novaloc and Locator on stability is essential for their potential prognosis ...
Ammar Omar Belal, Moataz Mostafa Bahgat Elmahdy, Sayed Mohammed Mohammed El Masry, Mohamed Ezzat Elsayed   +3 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Novel expandable short dental implants in situations with reduced vertical bone height—technical note and first results

International Journal of Implant Dentistry, 2017
Purpose Short implants often have the disadvantage of reduced primary stability. The present study was conducted to evaluate the feasibility and safety of a new expandable short dental implant system intended to increase primary stability.
Waldemar Reich, Ramona Schweyen, Christian Heinzelmann, Jeremias Hey, Bilal Al-Nawas, Alexander Walter Eckert   +5 more
doaj   +1 more source

Evaluation of implant stability using different implant drilling sequences

Journal of Dental Sciences, 2019
Simplifying the drilling sequence would be meaningful for implant surgery, if it does not exert a negative influence. This prospective clinical study was conducted to evaluate the stability of implant placements after simplifying the drilling sequence.Subjects were divided into a control group that underwent a normal drilling sequence or a test group ...
Hyeon Min Kim, Jin-yong Cho, Jaeyoung Ryu   +2 more
openaire   +3 more sources