Results 51 to 60 of about 202,406 (286)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

High density laminar recordings reveal cell type and layer specific responses to infrared neural stimulation in the rat neocortex

Scientific Reports
Infrared neural stimulation has consistently shown that temperature is a critical neuronal state variable. However, a comprehensive understanding of the biophysical background is essential.
Zsófia Balogh-Lantos, Richárd Fiáth, Ágoston Csaba Horváth, Zoltán Fekete   +3 more
doaj   +1 more source

Self‐powered technology based on nanogenerators for biomedical applications

Exploration, 2021
Biomedical electronic devices have enormous benefits for healthcare and quality of life. Still, the long‐term working of those devices remains a great challenge due to the short life and large volume of conventional batteries.
Yuanzheng Zhang, Xiangyang Gao, Yonghui Wu, Jinzheng Gui, Shishang Guo, Haiwu Zheng, Zhong Lin Wang   +6 more
doaj   +1 more source

Early Seizure Detection with an Energy-Efficient Convolutional Neural Network on an Implantable Microcontroller

, 2018
Implantable, closed-loop devices for automated early detection and stimulation of epileptic seizures are promising treatment options for patients with severe epilepsy that cannot be treated with traditional means.
Blum, Manuel, Boedecker, Joschka, Dümpelmann, Matthias, Heller, Simon, Hügle, Maria, Manzouri, Farrokh, Schulze-Bonhage, Andreas, Watter, Manuel, Woias, Peter   +8 more
core   +1 more source

Selecting patients with nonischemic dilated cardiomyopathy for ICDs [PDF]

, 2017
No abstract ...
Cleland, John G.F., Halliday, Brian P., Prasad, Sanjay K.   +2 more
core   +1 more source

NERVE IMPLANTS

, 2006
Synthetic materials have been used in the medical field for surgical grafts due to lack of insufficient organic graft prosthesis. In the first years of their development, properties of an ideal graft were defined. "An ideal graft must be durable on implantation, must be produced at the required dimension, must be biocompatible, must be inert, must be ...
openaire   +5 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Ultrasound‐Driven On‐Demand Transient Triboelectric Nanogenerator for Subcutaneous Antibacterial Activity

Advanced Science, 2023
To prevent surgical site infection (SSI), which significantly increases the rate morbidity and mortality, eliminating microorganisms is prominent. Antimicrobial resistance is identified as a global health challenge.
Iman M. Imani, Bosung Kim, Xiao Xiao, Najaf Rubab, Byung‐Joon Park, Young‐Jun Kim, Pin Zhao, Minki Kang, Sang‐Woo Kim   +8 more
doaj   +1 more source

Irradiation treatment of laryngeal cancer in a patient with an implantable cardioverter-defibrillator (ICD) [PDF]

, 2007
Background: Due to an aging population the incidence of both cardiac and tumor-related illnesses is increasing. A problem may arise if radiotherapy is necessary in close anatomic proximity to an implantable cardioverter-defibrillator (ICD).
Krimmel, Klaus, Schaffer, Moshe, Schaffer, Pamela Manuela, Sepe, Susanna   +3 more
core   +1 more source