Results 21 to 30 of about 27,260 (312)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Implantes zigomáticos na reabilitação do sistema estomatognático [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catatina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia.Os implantes zigomáticos são alternativas recentemente desenvolvidas para minimização de procedimentos cirúrgicos que ...
Hochheim Neto, Ricardo
core  

Implantation of the Subcutaneous Implantable Cardioverter-Defibrillator [PDF]

Circulation: Arrhythmia and Electrophysiology, 2017
Background— Alternative techniques to the traditional 3-incision subcutaneous implantation of the subcutaneous implantable cardioverter-defibrillator may offer procedural and cosmetic advantages. We evaluate 4 different implant techniques of the subcutaneous implantable cardioverter-defibrillator.
Brouwer, Tom F., Miller, Marc A., Quast, Anne-Floor B. E., Palaniswamy, Chandrasekar, Dukkipati, Srinivas R., Reddy, Vivek, Wilde, Arthur A., Willner, Jonathan M., Knops, Reinoud E.   +8 more
openaire   +3 more sources

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Avaliação da Precisão de Implantes Planejados com uso de Guia Cirúrgico Prototipado: Revisão de Literatura [PDF]

, 2013
TCC (graduação) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Odontologia.Devido aos esforços e na procura contínua para se chegar a técnicas que resultem em menor tempo cirúrgico, procedimentos menos invasivos e resultados mais ...
Hoffmann, Guilherme de Oliveira
core  

Fracturas de implantes de tibia. Consecuencias para los ensayos de los implantes [PDF]

, 1999
El objetivo de este trabajo es estudiar los modelos de fracturas de prótesis de tibia descritos en la literatura y, sobre la base de dichos conocimientos, desarrollar un ensayo para implantes en la cual se logren simular condiciones fisiológicas.
Heuberger, P., Frei, S., Ploeg, H., Reinschmidt, C.   +3 more
core   +1 more source

Hipoacusia de causa genética en cubanos con implante coclear

Revista Habanera de Ciencias Médicas, 2014
 Introducción: la hipoacusia neurosensorial es la forma más común de déficit auditivo. Presenta gran heterogeneidad clínica y etiológica; la frecuencia relativa de su causa varía de acuerdo con el método de estudio empleado.
María Belén Mattos Vélez, Estela Morales Peralta, Xeneida Isabel Hernandez Padilla, Sandra Elena Quintana Mirabal, Mirta Beatriz Álvarez Rivero, Yesy Martin Garcia, Gerda Alianna Alianna Gonzalez Sánchez   +6 more
doaj  

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source

Avaliação do grau de satisfação e da qualidade de vida de pacientes reabilitados com implantes osseointegrados submetidos à carga imediata [PDF]

, 2013
Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Odontologia.Problemas com retenção e estabilidade de próteses totais removíveis convencionais prejudicam a funcionalidade, a estética e as relações psicossociais de seus usuários. Sendo
Baschirotto, Taise Veronezi
core  

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source