Results 21 to 30 of about 19,178 (313)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

O uso de mini-implantes como ancoragem ortodôntica [PDF]

, 2011
TCC (graduação) - Universidade Federal de Santa Catarina, Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Curso de Odontologia.A ancoragem ortodôntica é decisiva para o sucesso do tratamento ortodôntico, onde dispositivos intra e ...
Schlickmann, Sérgio
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Hybrid Implant: A Novel Implant System [PDF]

Journal of Maxillofacial and Oral Surgery, 2014
Replacement of missing tooth has evolved from removable dentures to fixed dentures and recently to dental implants. The need of sufficient bone around the endosseous implant is critical for the success of the implant. The present study was aimed to evaluate the efficacy of a novel implant (HYBRID IMPLANT-submitted for patency) for replacement of the ...
Varghese, Mani, K K, Sivaprasad, Arun, George, V, Sankar Vinod, Miriam, Mathew, Susan, Paul   +5 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Influência dos fatores locais na prevalência da peri-implantite ao redor de implantes pilares de próteses totais fixas: estudo transversal [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em OdontologiaObjetivo: A proposta deste estudo foi avaliar a influência dos fatores locais na prevalência da peri-implantite em ...
Schuldt Filho, Guenther
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Análise de resistência mecânica em implantes de osso: um enfoque numérico e experimental [PDF]

, 2003
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Mecânica.Os implantes, utilizados atualmente em ortopedia e odontologia, apresentam inúmeros inconvenientes, dentre os quais se ...
Bento, Daniela Águida
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Hallazgos ecográficos sugestivos de contractura capsular en ultrasonidos mamarios del servicio de radiología del CMDLT en el período enero-agosto 2024.

Revista Científica CMDLT
Introducción: la contractura capsular (CC) es una complicación común en la mamoplastia de aumento, resultante de una respuesta inflamatoria exagerada al implante, que causa formación de una cápsula de tejido cicatricial.
Antonietta Alejandra Ramos Del Giaccio,, Alcira Margarita Capecchi Rodríguez   +1 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Implantes zigomáticos na reabilitação do sistema estomatognático [PDF]

, 2002
Dissertação (mestrado) - Universidade Federal de Santa Catatina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Odontologia.Os implantes zigomáticos são alternativas recentemente desenvolvidas para minimização de procedimentos cirúrgicos que ...
Hochheim Neto, Ricardo
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