Results 31 to 40 of about 3,109 (263)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Efectos de implantes, olaquindox y sexo sobre las características de la canal de cerdos

Revista Científica, 2010
Se utilizaron 54 cerdos Landrace y Yorkshire en un diseño completamente aleatorizado. El análisis de varianza-covarianza por cuadrados mínimos para cada raza, incluyo los efectos del sexo (hembras y machos castrados), tratamiento (DES = implante de
Nelson Huerta Leidenz, Enio Wilhelm, Guillermo Ríos Fuenmayor, Angel Páez, Edmundo Rincón, Nancy Jerez Timaure   +5 more
doaj  

Haste intramedular bloqueada em comparação com placa de compressão dinâmica na estabilização de osteotomia intertrocantérica varizante em cães: estudo ex vivo

Pesquisa Veterinária Brasileira
RESUMO: Tendo em vista as vantagens das hastes intramedulares bloqueadas (HIB) em relação às placas ósseas na estabilização femoral, o presente estudo objetivou avaliar a exequibilidade e eficácia da aplicação da HIB pós osteotomia intertrocantérica ...
Leandro Z. Carneiro, Maria L.A. Mistieri, Carlos R. Cauduro, Alisson F. Rosa, João P.E. Pascon   +4 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Efecto comparativo sobre la ganancia de peso de dos agentes anabólicos en mestizos Bos-indicus enteros y castrados a pastoreo

Revista Científica, 2010
En una finca comercial del Estado Zulia, ubicada en una zona de bosque húmedo (El Guayabo) se evaluó el efecto de implantes esteroides y no esteroides sobre la ganancia de peso, 80 bovinos mestizos divididos en dos grupos 40 enteros y 40 castrados, con ...
Nain Rubio Rubio, Néstor Montiel
doaj  

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Exodoncia, regeneración ósea, implantes, reporte de un caso

Revista Facultad de Odontología Universidad de Antioquia, 1999
There are many different indications for a tooth extraction. The decision is generally made by general dentists. The way the extraction is made will define the aesthetic and functional results of the final restoration.
Jorge Alberto Arismendi-Echavarria
doaj  

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Evidence of clinical and radiographic changes in machined and modified surface osseointegrated implants: 3 to 12 months follow up

Revista Facultad de Odontología Universidad de Antioquia, 2006
The aim of this study is to undertake a clinical and radiographic evaluation between two different patient groups: machined versus modified surface, to find out if there is statistically significant difference that support the use of implants with ...
Jorge A. Arismendi-E. , Catalina Castaño-G. , Richard M. Mejía-B. , Ana Lucía Mesa-J., Diego A. Castañeda-P. , Sergio I. Tobón-A.   +5 more
doaj  

Building a Framework for Sexual and Reproductive Health Care in the Rheumatology Context: Content and Approaches

Arthritis Care &Research, EarlyView.
People with systemic autoimmune and rheumatic diseases (SARDs) are at higher risk than the general population of experiencing adverse pregnancy and perinatal outcomes such as preeclampsia, intrauterine growth restriction, and maternal and/or fetal death.
Mehret Birru Talabi, Sonya Borrero
wiley   +1 more source