Results 51 to 60 of about 206 (188)

TRIM28‐Derived Peptide Exerts Anti‐Tumor Roles by Stabilizing Tumor Suppressive BRD7 Protein in Multiple Cancers

Advanced Science, EarlyView.
An α‐helical peptide, TAB12, designed to mimic the TRIM28 binding interface, competitively disrupts the TRIM28‐BRD7 interaction, thereby blocking ubiquitin‐mediated degradation of the tumor suppressor BRD7. This stabilization unleashes potent anti‐tumor effects across multiple tumor types with a favorable safety profile, offering a feasible strategy ...
Qingqing Wei, Changning Xue, Mengna Li, Jianxia Wei, Lemei Zheng, Shipeng Chen, Yijie Wang, Yumei Duan, Yanwei Luo, Wei Xiong, Ming Zhou   +10 more
wiley   +1 more source

circZNF148 Drives Glucose Metabolism Reprogramming to Enhance Metastasis and Immune Evasion via HK1 Stabilization in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
CircZNF148 stabilizes HK1 through deubiquitinase recruitment, thereby enhancing glycolysis and lactate production. Elevated lactate promotes PD‑L1 lactylation and membrane accumulation while suppressing CD8+ T‐cell cytotoxicity, collectively facilitating immune evasion and malignant progression in TNBC.
Yuhan Jin, Wenjing Zhao, Lei Wang, Jianing Wang, Keying Zhao, Dan Luo, Yifei Wang, Yuxia Yang, Jingze Yang, Yaming Li, Tong Chen, Dianwen Han, Zekun Wang, Xiaoyan Li, Bing Chen, Lijuan Wang, Yiran Liang, Qifeng Yang   +17 more
wiley   +1 more source

Effect of zafirlukast on capsular contracture around silicone implants in rats Efeito do zafirlukast na contratura capsular ao redor de implantes de silicone em ratos

Acta Cirúrgica Brasileira, 2012
PURPOSE: To evaluate the effect of zafirlukast on capsular contracture around silicone implants by measuring the pressure within the implant, using a rat experimental model. METHODS: Forty adult female Wistar rats were used.
Érika Malheiros Bastos, Miguel Sabino Neto, Élvio Bueno Garcia, Daniela Francescato Veiga, Yuri Anna Han, Rafael Denadai, Rafael de Almeida Santos, Lydia Masako Ferreira   +7 more
doaj   +1 more source

Livestock Multi‐Omics Integration: A Systematic Framework From Statistical Association to Causal Interpretation

Advanced Science, EarlyView.
A three‐tier livestock multi‐omics framework resolves four typical analytical pitfalls. Moving from statistical association through machine learning preprocessing to triple‐modal causal inference, it converts omics results into genomic selection and gene editing strategies to achieve One Health, underpinned by multi‐omics data, multimodal sequencing ...
Jiying Wen, Zhongyu Wang, Jieping Huang, Fen Li, Ningbo Chen, Yun Ma   +5 more
wiley   +1 more source

Implantes complementares na reconstrução mamária Supplementary implants in breast reconstruction

Revista Brasileira de Cirurgia Plástica, 2012
INTRODUÇÃO: A depressão na parede anterior da axila pós-mastectomia gera insatisfação das pacientes ao vestirem roupas mais decotadas; além disso, pode haver dificuldade na elevação do braço quando há aderências e retrações nessa região. Nessas pacientes,
João Medeiros Tavares Filho, Manoel Belerique, Diogo Franco, Guilherme Arbex, Marcio Arnaut Junior, Talita Franco   +5 more
doaj   +1 more source

Hematoma tardío, una complicación rara de los implantes de mama [PDF]

Cirugía Plástica, 2020
Luis Tamez-Pedroza,  Iram González-Vargas, Francisco Palacios-Luna,  Mauricio Manuel  García-Pérez   +3 more
openaire   +1 more source

Pathophysiologic Consequences of Early Coarctation Stenting in a Longitudinal Porcine Model

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Novel stent technologies offer early intravascular treatment options for coarctation (COA). Mid‐to‐long‐term cardiovascular responses to early COA stent interventions are undefined. Aims We studied a porcine model of COA, with and without early stent implantation with serial dilation to adult aortic diameters, aiming to define ...
Leah M. Gober, Michael A. Stellon, Matt A. Culver, Amy Frenkel, Dana Irrer, Colleen M. Witzenburg, Alejandro Roldán‐Alzate, Luke Lamers   +7 more
wiley   +1 more source

Implant? Prosthesis? Inclusion? Implante? Prótese? Inclusão?

Revista Brasileira de Cirurgia Plástica, 2011
The author discusses the indiscriminate use of various terms to designate a single artifact and suggests the adoption of only one signifier. Although no publications deal specifically with the meaning of the terms "implant", "prosthesis" or "inclusion ...
César Augusto Arrunátegui Carvallo
doaj   +1 more source

Percutaneous Transaxillary Access for Large‐Bore Cardiovascular Interventions: Evidence, Technique, and Complication Management

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Percutaneous transaxillary access is an established alternative to transfemoral large‐bore arterial access for transcatheter structural heart interventions and mechanical circulatory support (MCS). Although useful for overcoming hostile iliofemoral anatomy and providing prolonged support and patient mobilization in case of MCS, the axillary ...
Gioel Gabrio Secco, Marco Lombardi, Edoardo Elia, Juan Guido Chiabrando, Andrea Demarchi, Rocco Vergallo, Andrea Audo, Giulia Maj, Giuseppe Patti, Nicolas M. Van Mieghem   +9 more
wiley   +1 more source

Reacción tisular a las prótesis mamarias. Contractura capsular periprotésica

Anales del Sistema Sanitario de Navarra, 2008
Las prótesis mamarias de silicona provocan el desarrollo de una envoltura fibrosa o cápsula periprotésica. La contractura de la cápsula, por retracción del tejido fibroso, es la complicación más frecuente e importante de estos implantes.
F.J. Escudero, R. Guarch, J.A. Lozano
doaj