Results 91 to 100 of about 9,117,130 (287)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

TQM implementation: An empirical examination and proposed generic model [PDF]

, 2001
Total quality management (TQM) is considered by many as an important quality and business performance improvement tool. The popularity of the concept has led to an explosion of TQM related literature.
Ghobadian, A, Ghobadian, A., Gallear, D, Gallear, D.   +3 more
core   +1 more source

Creating system-wide change in medicine: The role of implementation science in achieving scale and adoption

Future Healthcare Journal
Delivering meaningful change in healthcare is less about new discoveries and more about ensuring adoption at scale of what is already known to work.
Simon Barry, Chris Davies
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

A Full-Cycle Analysis of the EPIS Framework: Exploration, Preparation, Implementation, Sustainment

Xiehe Yixue Zazhi
Implementation science aims to facilitate the efficient dissemination and sustainable application of evidence based interventions, and has accordingly generated a variety of theories, models, and frameworks.
HUANG Zizhen, XU Dong, ZHONG Dongmei, NING Zhiqing, ZHU Junlin, LI Qingqing, HUANG Wanqing, Kera Swanson, Gregory A. Aarons   +8 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

A roadmap for developing a program to self-manage post-traumatic knee osteoarthritis risk

Osteoarthritis and Cartilage Open
Youth and young adults who experience a traumatic knee injury (i.e., ligament, meniscus, or cartilage injury; intra-articular fracture or dislocation) have a 6-fold elevated risk of early-onset post-traumatic knee osteoarthritis (PTOA), contributing to ...
Jackie L. Whittaker, Alison M. Hoens, Candice Archibald, Michael A. Hunt, Christina Y. Le, Justin M. Losciale, Maxi Miciak, Amber D. Mosewich, Trish Silvester-Lee, Linda K. Truong, Dominic Wade, Ewa M. Roos, Linda C. Li   +12 more
doaj   +1 more source

"Mind-Blowing"": Fostering Self-Regulated Learning in Information Literacy Instruction

Communications in Information Literacy, 2015
The new ACRL Framework for Information Literacy for Higher Education brings a new emphasis into our instruction on student metacognition and dispositions. In this article I introduce self-regulated learning, a related concept from the field of education;
Eveline Houtman
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source