Results 101 to 110 of about 4,591,188 (299)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Intention-Aware Multiagent Scheduling

, 2020
The Belief Desire Intention (BDI) model of agency is a popular and mature paradigm for designing and implementing multiagent sys- tems. There are several agent implementation platforms that follow the BDI model.
Brian Logan (15470308), Yuan Yao (31223), Michael Dann (18027040), John Thangarajah (8812517)   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Linking Perceived Policy Effectiveness and Proenvironmental Behavior: The Influence of Attitude, Implementation Intention, and Knowledge. [PDF]

Int J Environ Res Public Health, 2021
Wang H, Li J, Mangmeechai A, Su J, Su J.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Forming a new prospective memory intention can reduce prospective memory commission errors

Humanities & Social Sciences Communications
Previous prospective memory (PM) studies indicate that PM intentions remain active after completion and result in commission errors. In this study, we aimed to investigate the effect of adding a new PM intention in the finished phase on PM commission ...
Yunfei Guo, Jiaqun Gan, Yongxin Li
doaj   +1 more source

The Influence of Work Environment and Career Development on Turnover Intention With Coaching as an Intervening Variable

Lentera Perawat
Work environment and career development are crucial factors influencing turnover intention among nurses. Coaching can act as an intervening variable that strengthens the relationship between these factors and turnover intention.
Dwi Agustina, Intan Silviana Mustikawati, Erry Yudhya Mulyani   +2 more
doaj   +1 more source

Customer Intention toward Theme Park: The Mediating Role of Customer Attitude on The Impact of Service Quality and Experiential Marketing

Journal the Winners, 2012
Dunia Fantasi (Dufan) located in Taman Impian Jaya Ancol is one leading recreational unit with specific characteristics as a theme park. A research was done towards with service quality and implementation of experiential marketing applied in Dufan using ...
Dwi Efrarin Purnamadita, Dian Tauriana
doaj   +1 more source

Specificity of Implementation Intention Encoding

, 2015
Investigating whether the components of implementation intention encoding (visualization, structured statement) affect how specifically participants encode a category-cue prospective memory ...
Michael Scullin
core   +1 more source