Results 111 to 120 of about 7,741,883 (356)

An intervention modelling experiment to change GP's intentions to implement evidence-based practice : using theory-based interventions to promote GP management of upper respiratory tract infection without prescribing antibiotics #2 [PDF]

, 2008
Background: Psychological theories of behaviour may provide a framework to guide the design of interventions to change professional behaviour. Behaviour change interventions, designed using psychological theory and targeting important motivational ...
A Bandura, A Bandura, AM Mathews, B Arroll, CC Butler, D Blackman, D Bonetti, D Bonetti, Department of Health, Eileen FS Kaner, EM McColl, GL Paul, House of Lords Select Committee on Science and Technology, I Ajzen, J Francis, Jeremy Grimshaw, Jill Francis, JM Grimshaw, M Ashworth, M Ashworth, Marie Johnston, Martin Eccles, Medical Research Council, MJ Norusis, MP Eccles, Nick Steen, PM Gollwitzer, RM Baron, S Smith, SD Halpern, Standing Medical Advisory Committee.Subgroup on Antimicrobial Resistance, Susan Hrisos, T Sobel   +32 more
core   +5 more sources

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Factors affecting e-government adoption in the state of Qatar [PDF]

, 2010
Electronic government (e-government) initiatives are in their early stages in many developing countries and faced with various issues pertaining to their implementation, adoption and diffusion.
Al-Shafi, S, Weerakkody, V
core   +1 more source

Goal conflict, goal facilitation, and health professionals' provision of physical activity advice in primary care : An exploratory prospective study [PDF]

, 2011
Peer reviewedPublisher ...
Campbell, Neil C, Francis, Jill J, Presseau, Justin, Sniehotta, Falko F   +3 more
core   +5 more sources

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Implementation of Internet of Things depends on intention: young farmers’ willingness to accept innovative technology

, 2020
Innovative applications of smart technology constitute a current trend in agricultural development.
Jui-Hsiung Chuang, Jiun-Hao Wang, Chaoyun Liang   +2 more
semanticscholar   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

A Configurable Matchmaking Framework for Electronic Marketplaces [PDF]

, 2004
E-marketplaces constitute a major enabler of B2B and B2C e-commerce activities. This paper proposes a framework for one of the central activities of e-marketplaces: matchmaking of trading intentions lodged by market participants. The framework identifies
Boualem Benatallah, Chavez, Di Noia, Gamma, Halpin, Lee, Lewis, Li, Marlon Dumas, Medjahed, Murray Spork, Nick Russell, Rachlevsky Reich, Rumbaugh, Schmid, Ströbel, Ströbel, Trastour, Tsvetovatyy, Wurman   +19 more
core   +3 more sources

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source