Results 91 to 100 of about 60,129 (261)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Implementing health research through academic and clinical partnerships : a realistic evaluation of the Collaborations for Leadership in Applied Health Research and Care (CLAHRC) [PDF]

, 2011
Background: The English National Health Service has made a major investment in nine partnerships between higher education institutions and local health services called Collaborations for Leadership in Applied Health Research and Care (CLAHRC).
Baker, R, Martin, G, G. Harvey (6109268), Baker Richard, Graham, Ian D., Burton, C., McCormack Brendan G, Rycroft-Malone, Jo, McCormack, Brendan, Graham, I, Thompson, C, Joyce E Wilkinson, Rycroft-Malone, J, Thompson, Carl, Baker, Richard, I. Graham (7334894), Harvey, G, Staniszewskas, Sophie, Martin, Graham, Burton, Christopher R., Sophie Staniszewska, S. Staniszewska (4327975), Graham, Ian, Graham Martin (3571220), Andrews, G, Andrews Gavin, Graham Martin, Andrews, Gavin, Burton, CR, Martin, Graham P., Wilkinson, J.E., Ariss, S, Harvey Gill, Christopher R Burton, Dopson, Sue, Andrews, G., Steven Ariss, McCormack, B.G., J. E. Wilkinson (7620728), Rycroft-Malone Jo, McCormack, Brendan G., Richard Baker, Martin, G., C. Thompson (7620746), Ariss, Steven, Burton, C.R., McCormack, B., Wilkinson, Joyce, Andrews, Gavin J., Wilkinson Joyce E, J. Rycroft-Malone (6164171), Richard Baker (301808), G. Andrews (7620734), Wilkinson, Joyce E., Harvey, Gill, Rycroft-Malone, J., Wilkinson, J., Brendan G McCormack, Wilkinson, Joyce E, Baker, R., Ian Graham, Martin Graham, Ariss Steven, B. G. McCormack (7620743), Dopson, S., Gill, Harvey, Gavin Andrews, Graham, I., Harvey, G., Thompson Carl, Staniszewska, S., Sue Dopson, Dopson, S, Staniszewska, S, Staniszewska Sophie, Burton Christopher R, McCormack, BG, Thompson, Carl, DPhil, Staniszewska, Sophie, S. Dopson (7620740), Burton, Christopher R, C. R. Burton (7620731), Graham Ian, Gill Harvey, Dopson Sue, Wilkinson, JE, S. Ariss (7620737), Carl Thompson, Thompson, C., Jo Rycroft-Malone, Burton, Christopher, Ariss, S.   +91 more
core   +1 more source

Transformational change leadership framework for implementing Broad-Based Black Economic Empowerment in South African organisations

Acta Commercii, 2019
Orientation: This multiple qualitative case study provides a change leadership framework through augmentation of Kotter’s eight-step change leadership model.
Corlé Grobler, René van Wyk, Mpho D. Magau   +2 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Dialogue Summary: Improving Leadership Capacity in Community Care in Ontario [PDF]

, 2015
A summary of what was learned from a stakeholder dialogue that addressed problems related to leadership capacity, options for addressing these problems, key implementation considerations, and next steps for improving leadership capacity in community care
Moat, KA, Bullock, Heather, Lavis, JN
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effects of Site Leadership on Technology Implementation: A Quantitative Case Study

, 2020
The purpose of this study was to better understand how teachers can effectively implement technology in their lesson design and to identify factors that may influence the implementation of technology.
Chad T. Freeman
core  

Correlations Between Leadership, Self-Efficacy, and Evidence-Based Practice Competency in Nursing in a Chinese Tertiary Hospital

Risk Management and Healthcare Policy
Jing Li,1,* Ya-Qi Liu,2,* Jia Song,3 Xu-Fang Huang,1 Mei-Fen Chen1 1Department of Nursing, The Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, Lishui, Zhejiang, 323000, People’s Republic of China; 2School of ...
Li J, Liu YQ, Song J, Huang XF, Chen MF
doaj