Results 171 to 180 of about 29,393,528 (376)

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Implementing R and D policies : an analysis of Spain's pharmaceutical research program [PDF]

, 2003
Using detailed firm-level data, we analyze Spain's Pharmaceutical Research Program, and find differences between the ex ante announced evaluation criteria and their ex post implementation.
Desmet, Klaus, García, Clara Eugenia, Kujal, Praveen, Lobo, Félix   +3 more
core   +1 more source

Developing preparedness for flexible delivery of training in enterprises

, 2002
On a basis of research and literature review, Smith, in 2001, suggested a model for the development of preparedness of learners and their workplaces to support the flexible delivery of training in enterprises.
Robertson, Ian, Smith, Peter, Wakefield, Lyn   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Building health research infrastructure in Rwanda

The Lancet Global Health, 2014
Rwandan Research and Implementation Writing Group
doaj   +1 more source

THE DESIGN AND IMPLEMENTATION OF OLAP SYSTEM. CASE STUDY – UNIVERSITY RESEARCH [PDF]

The aim of this study is to show that multidimensional modelling of existing data in organizations, depending on the topics of interest of managers and multidimensional view of data.
Assoc. Prof. Carmen Radut Ph. D, Lect. Cristina Tenovici Ph. D, Prof. Georgeta Şoavă Ph. D   +2 more
core  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Patient engagement and shared decision-making in trial recruitment intervention studies: a systematic review

Research Involvement and Engagement
Background Supporting participation decisions and experiences in clinical trials is a persistent challenge that could be improved by two areas: patient engagement (PE), which involves actively collaborating with patients to enhance research relevance and
Tamara L. Morgan, Natasha Hudek, Kelly Carroll, Mei-Lin Yee, Juliette Inglis, Dean A. Fergusson, Katie Gillies, Dawn P. Richards, Seana N. Semchishen, Justin Presseau, Jeremy Grimshaw, Ian D. Graham, Marc Rodger, Monica Taljaard, Susan Marlin, Charles Weijer, Graeme MacLennan, Jamie C. Brehaut   +17 more
doaj   +1 more source

The role of economics in the QUERI program: QUERI Series. [PDF]

Background: The United States (U.S.) Department of Veterans Affairs (VA) Quality Enhancement Research Initiative (QUERI) has implemented economic analyses in single-site and multi-site clinical trials.
Barnett, Paul G, Smith, Mark W
core   +1 more source