Results 171 to 180 of about 28,489,203 (383)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The quality of district plans and their implementation: Towards environmental quality [PDF]

, 2002
Since inception of the Resource Management Act 1991 (RMA) the issue of sustainable management has dominated planning practice in New Zealand. Over the past decade, councils have wrestled with converting the concept of sustainable management into policy
Backhurst, Michael, Berke, Philip, Chapman, Sarah, Crawford, Janet, Day, Maxine, Dixon, Jennifer, Ericksen, Neil, Laurian, Lucie   +7 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Cost-Effectiveness of Interventions Related to the Treatment of Women With Polycystic Ovary Syndrome: A Scoping Review

International Journal of Women's Health
Emily Joy Callander,1,2 Yanan Hu,1 Alayna Carrandi,2 Chau Thien Tay,2 Aya Mousa,2 Helena Teede2 1School of Public Health, University of Technology Sydney, Sydney, NSW, Australia; 2Monash Centre for Health Research and Implementation, Monash University ...
Callander EJ, Hu Y, Carrandi A, Tay CT, Mousa A, Teede H   +5 more
doaj  

Epidemiology of sickle cell disease in tribal population of Southern Rajasthan, India

Scientific Reports
Background & objectives Sickle Cell Disease (SCD), a genetic condition, carries significant public health implications due to its impact on mortality, morbidity and quality of life. SCD is prevalent among tribal communities.
Anil Purohit, Ramesh K. Huda, Suman S. Mohanty, Bontha V. Babu   +3 more
doaj   +1 more source

ANALISIS PENGUATAN PROFIL PELAJAR PANCASILA MELALUI KEGIATAN SRAWUNG BUDAYA PADA KELAS 4 SD NEGERI 2 SUMBERBENING [PDF]

The curriculum used in education today is the Independent Curriculum. In its implementation, students must have character that is based on Pancasila. This is known as the Pancasila Student Profile.
Ramadhani, Prilly Tiya
core  

Developing preparedness for flexible delivery of training in enterprises

, 2002
On a basis of research and literature review, Smith, in 2001, suggested a model for the development of preparedness of learners and their workplaces to support the flexible delivery of training in enterprises.
Robertson, Ian, Smith, Peter, Wakefield, Lyn   +2 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Developing a theory of change to guide the design and implementation of a caregiver-centric support service

BMC Health Services Research
Background Set against the backdrop of a rapidly ageing population and growing emphasis on the importance of ageing-in-place, family members often assume the role of a caregiver.
Ling Ting Wu, George Frederick Glass, Esther Yin Hui Chew, Emmalene Joo Yong Ng, Ee Yuee Chan   +4 more
doaj   +1 more source

Program evaluation models and the implementation of research findings.

, 1968
Herbert C. Schulberg, Frank Baker
openalex   +2 more sources